MachOne生物活體組織電位測(cè)試分析系統(tǒng)，材料機(jī)電特性測(cè)試分析系統(tǒng),軟骨等流動(dòng)電位測(cè)試分析評(píng)估系統(tǒng)

型號(hào):MachOne，
聯(lián)系人:李先生
聯(lián)系電話:18618101725
品牌:BMM

世聯(lián)博研公司提供2款加拿大BMM 品牌的機(jī)電特性測(cè)試分析系統(tǒng)：

MachOne可以在壓縮期間同時(shí)測(cè)量電勢(shì)分布，系統(tǒng)可以活體在體測(cè)試軟骨、骨的壓電流動(dòng)電位。

1、MachOne多功能組織材料生物力學(xué)特性、電位分布測(cè)試分析表征系統(tǒng)
-多載荷多物理場(chǎng)耦合微觀力學(xué)性能原位測(cè)試系統(tǒng)

該BMM 材料/組織機(jī)電耦合效應(yīng)特性測(cè)試儀（機(jī)械力偶聯(lián)電位測(cè)試分析），可帶電活性組織或材料進(jìn)行機(jī)械力偶聯(lián)電位測(cè)試分析,比如關(guān)節(jié)軟骨、帶電水凝膠等活組織壓縮期間同步進(jìn)行電位測(cè)試,可集成3D輪廓表面形貌表征、拉伸、壓縮、三彎曲、四點(diǎn)彎曲、扭力、剪切、摩擦磨損、電特性等各種力電多物理場(chǎng)測(cè)試。能對(duì)極軟、極硬組織材料進(jìn)行精密可靠的機(jī)械刺激和表征。允許表征的機(jī)械性能包括剛度、強(qiáng)度、模量、粘彈性、塑性、硬度、附著力、腫脹和松弛位移控制運(yùn)動(dòng)各種機(jī)械特性

特點(diǎn)

1、適用樣品范圍廣：

1.1、從骨等硬組織材料到腦組織、眼角膜等軟組織材料

1.2、從粗椎間盤的樣品到j(luò)細(xì)纖維絲

2、通高量壓痕測(cè)試分析

2.1、三維法向壓痕映射非平面樣品整個(gè)表面的力學(xué)特性

2.2、48孔板中壓痕測(cè)試分析

3、力學(xué)類型測(cè)試分析功能齊

模塊化集成壓縮、張力、剪切、摩擦、扭轉(zhuǎn)、穿刺、摩擦和2D/3D壓痕、3D表面輪廓、3D厚度等各種力學(xué)類型支持,微觀結(jié)構(gòu)表征及動(dòng)態(tài)力學(xué)分析研究

4、高分辨率:

4.1、位移分辨率達(dá)0.1um

4.2、力分辨率達(dá)0.025mN

5、行程范圍廣：50-250mm

6、體積小巧、可放入培養(yǎng)箱內(nèi)

7 、高變分辨率成像跟蹤分析

8、多軸向、多力偶聯(lián)刺激

9、活性組織電位分布測(cè)試分析

10、產(chǎn)品成熟，文獻(xiàn)量達(dá) 上千篇

機(jī)電測(cè)試室如下：
該腔室設(shè)計(jì)用于在機(jī)電活性材料（例如結(jié)締組織，帶電水凝膠等）壓縮期間同步測(cè)量電勢(shì)分布。該腔室具有5個(gè)差分Ag-AgCl電極通道和一個(gè)較大的參比電極。圓形電極直徑為1毫米，它們之間（中心到中心）的距離為4毫米。可根據(jù)要求提供定制的幾何形狀。腔室可以充滿PBS溶液。

點(diǎn)與特點(diǎn)
該附件的設(shè)計(jì)便于清潔和消毒。
此零件設(shè)計(jì)堅(jiān)固，可保持其完整性多年
設(shè)計(jì)用于與生理鹽水溶液接觸
易于組裝和安裝在測(cè)試儀上
由透明材料制成，方便組裝

技術(shù)指標(biāo)：

材質(zhì)：Ag-AgCl（電極）
直徑：1 mm（電極）
間距：4 mm（中心到中心）（電極）

文獻(xiàn)案例：

1、結(jié)締組織的機(jī)電性能表征-

CHARACTERIZATION OF ELECTROMECHANICAL PROPERTIES OF CONNECTIVE TISSUES - PART 1 - ARTICULAR CARTILAGE
In this case study, the MachOne mechanical tester was used to determine the electromechanical properties of two connective tissues: the cartilage and the meniscus. Since tissue stiffness and compression-generated electric fields, or streaming potentials, are sensitive to the biochemical content of the tissue, the tester was coupled with an array of electrodes that can precisely measure these electric signals. The objective of this study was to establish links between biochemical composition and electromechanical properties (stiffness and streaming potentials) of normal and degenerated connective tissues. The first part of the study focuses on articular cartilage.
Since the articular cartilage extracellular matrix is primarily composed of negatively charged proteoglycans entrapped in a collagen network, there is an excess of mobile positive charges in the fluid. Compression of the cartilage produces streaming potentials via the separation of positively charged mobile ions relative to the fixed negatively charged proteoglycans.
Matched pairs of bovine cartilage/bone disks (3 mm in diameter) were cultured with and without a degradation agent (interleukin-1 or IL-1) for 11 days.
Electromechanical properties of the cartilage were evaluated by incorporating an array of electrodes into a testing chamber mounted on the MachOne. The MachOne is designed for various testing protocols including stress relaxation, sinusoidal displacement and creep in different configurations (confined and unconfined compressions, tension, indentation and bending). In this study, streaming potentials across the tissue surface are measured in unconfined compression geometry with a linear array of 8 platinum electrodes of 50 um diameter separated by 300 um. Electrodes 1 to 6 covered the 1.5 mm cartilage disk radius, and electrodes 7 and 8 were external to the cartilage in the bath. The testing chamber was filled
with physiological saline solution. A static compression offset of 100 μm was applied in a sequence of small step compressions of 20 μm at 2 μm/s. Dynamic sinusoidal tests were performed at frequencies of 1, 0.1 and 0.01 Hz with displacement amplitudes of 8, 4 and 2 μm. The streaming potential radial profile was constructed by the addition of each channel in the complex domain. Proteoglycan or glycosaminoglycan (GAG) content in the disk and content lost to the media during the culture was measured with the dimethylmethylene blue dye and spectrophotometry.
Figure 3 shows the GAG content in cartilage disks during the culture. The IL-1 treated disks lost 10, 20, 65 and 75% of their GAG content after 1, 4, 7 and 11 days of culture respectively. The MachOne is easy to use and its modular software permits a direct and rapid analysis of the dynamic sinusoidal test results. Figure 4 shows that dynamic stiffness was 3 times lower for the IL-1 treated disks compared to control after 11 days of culture.
The analysis of the stress relaxation test results showed that, at the end of the culture, the static stiffness was 4 times lower for degraded disks compared to control (0.3 MPa). Figure 5 shows the streaming potential profiles after 11 days of culture for normal and degraded cartilage. We observed that the profile potential gradient at the periphery for the IL-1 treated explants was reduced by half compared to control disks only one day after the beginning of the culture. The potential profile amplitude at the center of the disk was significantly lower for degraded disks compared to control explants after 7 days of culture.
The MachOne mechanical tester coupled with an array of electrodes can precisely determine the electromechanical properties of a large range of normal and degraded connective tissues.
2、結(jié)締組織的機(jī)電性能表征-2部分-半月板

CHARACTERIZATION OF ELECTROMECHANICAL PROPERTIES OF CONNECTIVE TISSUES - PART 2 - MENISCUS
In this case study, the MachOne mechanical tester was used to determine the electromechanical properties of two connective tissues; the cartilage and the meniscus. Since tissue stiffness and compression-generated electric fields, or streaming potentials, are sensitive to the biochemical content of the tissue, the tester was coupled with an array of electrodes that can precisely measure these electric signals. The objective of this study was to establish links between biochemical composition and electromechanical properties (stiffness and streaming potentials) of normal and degenerated connective tissues. The second part of the study focuses on meniscus.
The meniscus is a tissue similar to cartilage but softer and less charged. In this case, the samples have been sectioned to five 3-mm disks (about 1-2 mm thick) from various specified regions. Dynamic stiffness under unconfined compression and the streaming potential distribution are measured. It should be noted that the streaming potential are around 10 times lower for meniscus than cartilage (refer to Part 1 of this case study). These results also indicate that the dynamic stiffness and the streaming potential profiles are higher on the cartilaginous surface of the inner part of the meniscus (disk 1 and 2) compared to middle zones (disks 3 and 5). It is expected that these results are directly related to the proteoglycan content of menisci.
The MachOne mechanical tester coupled with an array of electrodes can precisely determine the electromechanical properties of a large range of normal and degraded connective tissues.

2、軟骨等流動(dòng)電位測(cè)試分析評(píng)估系統(tǒng)

?是一種手持式醫(yī)療設(shè)備，設(shè)計(jì)用于關(guān)節(jié)鏡手術(shù)，以評(píng)估關(guān)節(jié)軟骨的功能特性。通過壓縮軟骨表面，?測(cè)量流動(dòng)電位并計(jì)算反映軟骨健康狀態(tài)的定量參數(shù)。

Benchtop ?可對(duì)關(guān)節(jié)軟骨進(jìn)行j確的wu損評(píng)估。它計(jì)算了一個(gè)定量參數(shù)，反映了每個(gè)測(cè)量部位的關(guān)節(jié)軟骨的生化成分和承重特性。它是為有興趣僅在離體關(guān)節(jié)軟骨上使用該工具的研究人員開發(fā)的。提供非wu菌一次性吸頭，可配備配備高分辨率相機(jī)和相機(jī)定位軟件的測(cè)試室，用于繪制大型骨軟骨樣本。

軟骨研究

Benchtop ?在軟骨修復(fù)領(lǐng)域提供了大量研究機(jī)會(huì)。它非常寶貴：

了解軟骨疾病，包括軟骨退化的潛在原因
開發(fā)新的治療產(chǎn)品和軟骨修復(fù)技術(shù)
可靠的骨關(guān)節(jié)炎動(dòng)物模型的概念
創(chuàng)建各種物種的參考映射

工作原理：

臺(tái)式?測(cè)量關(guān)節(jié)軟骨的壓縮誘導(dǎo)的流動(dòng)電位。在溫和壓縮軟骨表面期間使用壓頭測(cè)量這些電信號(hào)（參見下圖）。te的壓頭設(shè)計(jì)包括覆蓋有37個(gè)微電極陣列的球形表面。
該裝置計(jì)算軟骨機(jī)電活動(dòng)的定量參數(shù)（QP），其對(duì)應(yīng)于當(dāng)其流動(dòng)電位的總和達(dá)到100mV時(shí)與軟骨接觸的微電極的數(shù)量。高QP表示弱機(jī)電特性，反之亦然。 QP是可再現(xiàn)的，并且與施加的力和壓頭取向wu關(guān)。

健康的軟骨正常流動(dòng)電位:

在正常軟骨被壓縮時(shí)，相對(duì)于包埋在膠原網(wǎng)絡(luò)內(nèi)的帶負(fù)電荷的蛋白聚糖，間質(zhì)液的流動(dòng)取代帶正電的移動(dòng)離子。這產(chǎn)生稱為流動(dòng)電位的電位。

關(guān)節(jié)炎軟骨低流動(dòng)電位:

退化的軟骨的特征在于蛋白多糖的喪失和膠原網(wǎng)絡(luò)的減弱。由于相對(duì)于帶負(fù)電的蛋白多糖，正離子的位移較小，因此關(guān)節(jié)炎軟骨的壓縮產(chǎn)生異常低的流動(dòng)電位。

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Quantitative assessments of articular cartilage function are needed to aid clinical decision making. Our objectives were to develop a new electromechanical grade to assess quantitatively cartilage quality and test its reliability. Electromechanical properties were measured using a hand-held electromechanical probe on 200 human articular surfaces from cadaveric donors and osteoarthritic...Read More

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Freeze-Dried Chitosan-PRP Injectable Surgical Implants for Meniscus Repair: Pilot Feasibility Studies in Ovine ModelsGhazi Zadeh L, Chevrier A, Hurrtig MB, Farr J, Rodeo S, Hoemann CD and Buschmann MDRegen Med Ther, 1(1) 16-29. (2017)

Clinical management of meniscus tears often involves partial meniscectomy, which can lead to Osteoarthritis (OA). Meniscus repair augmentation strategies are being developed to compensate for the tissue’s limited healing response. The purpose of the study was to assess the feasibility of using implants composed of freeze-dried Chitosan (CS) solubilized in Platelet-Rich Plasma (PRP) to improve...Read More

Osteochondral Repair and Electromechanical Evaluation of Custom 3D Scaffold Microstructured by Direct Laser Writing LithographyJ. Maciulaitis, M. Miskiniene, S. Rekstyte, M.Bratchikov, A. Darinskas, A.Simbelyte, G. Daunoras, A. Laurinaviciene, A. Laurinavicius, R. Gudas, M. Malinauskas and R. MaciulaitisCartilage · May 2019, https://doi.org/10.1177/1947603519847745

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