Standard features
◆Pressure 0~207Mpa (2070bar)
◆Flux 500ml/min (30L/h)
◆Power Required 380V 5.5KW
◆Process, including inlet, treating process and outlet of the sample, can be operated in the sink (Can add ice into the sink)
◆Process including inlet, treating process and outlet of the sample, can be operated in 4~6℃ circulation water bath (An optional special circulation cooling device is available)


Typical Applications
It is suitable for universities; research Institutes, high-tech companies, Institutes of Biological Products etc.
1)Cell disruption, such as E.coli, Yeast, Soproderm, Nematode, and Plant cells, Actinomycetes, Thermophilic bacteria, Mycobacterium.
2)Preparation and Isolation of Enzymes; preparation of recombinant polypeptide.
3)Crystal engineering; protein crystal
4)Nano-homogenization of emulsion and liposome etc.
5)Mutation breeding of high-pressure.
6)Nano ink, nano-paint, nano-dye,micronization

Principle
Low Temperature Ultra-high Pressure Continuous Flow Cell Disrupter is achieved by high pressure forcing the sample through a small orifice at high speed. At the effect of the shearing, hole and impact, cells of the sample are crushed; substances of the sample are dispersed and emulsified. And the active biological substance would be kept the activity at the crash which operate in 4℃~6℃ circulating water bath.

Characteristics
◆Globally unique operation, which inlet, treating process and outlet of the sample operate in 4~6℃ circulation water bath, to keep the activity of substances. (An optional special circulation cooling device is required)
◆The global leading ultra-high pressure of 207Mpa，satisfy various requirements.
◆Key component is imported from Germany, with a longer service life.
◆Adopted hydraulic power; the pressure of the equipment is stable, even operate on and off randomly under high pressure.
◆Advanced and new pollution-free materials fit the food production and drug manufacture’s requirements.
◆Original washing system and imported, inner wall mirror polished 316 L stainless steel pipes, to prevent residue samples.
◆Metal seals can be cleaned up and sterilized in situ.
◆Automatic sampling, continuous process.
◆The pump is made of high-strength stainless-steel.
◆Utilizing mechanical cell disintegration, no chemical residue.
◆Convenient maintenance, cost-effective.


Examples of application
●Soproderm-broken ratio of Ganoderma Lucidum Spores can reach to 95~99%.
●Loss rate of one enzyme activity in actinomycete is only 4.8%.
●Disruption rate of Yeast and E.coli can reach to 95~99%.
●The average size of nano-emulsified liposome is 53.68nm; the minimum size can be up to 28.2nm.

Some Honorable Customers in China
Research Institutions and Production-oriented Companies：
1. Beijing Institute of Genomics, Chinese Academy of Sciences
2. Institute of Biophysics Chinese Academy of Sciences
3. Institute of High Energy Physics Chinese Academy of Sciences
4. Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences, CAS
5. Institut Pasteur of Shanghai Chinese Academy of Sciences
6. Shanghai Institute of Applied Physics, Chinese Academy of Sciences
7. Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (CAS)
8. Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences, CAS( Phase II)
9. Shanghai Institute of Materia Medica , Chinese Academy of Sciences
10.Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences (TIB, CAS.)
11.CanSino Biotech Inc.
12.Wuhan Institute Of Virology,Chinese Academy Of Sciences
13.Institute of Pathogen Biology, Chinese Academy of Medical Sciences& Peking Union Medical College
14.Institute of Basic Medical Sciences (IBMS) of Chinese Academy of Medical Sciences (CAMS) and School of Basic Medicine (SBM) of Peking Union Medical College (PUMC)
15.Institute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences
16. National Institute of Biological Sciences, Beijing
17. Shanghai Pharma
18. Shanghai Institute of Pharmaceutical Industry
19.Tianjin International Joint Academy of Biotechnology&Medicine
20.Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences
21. PLA 309 Hospital
22.Shanghai Institute of Hematology,School of medicine, Shanghai Jiaotong University
23. Pearl River Fishery Research Institute，Chinese Academic of Fishery Science
24. Roche China
25. DIAO Group
26. NEPTUNUS
27. National Engineering Research Center for Nanomedicine & Institute of Materia Medica
28. Nanning fermentation and enzyme engineering technology research center
29. Guangxi Academy of Sciences
30. Dongguan agricultural scientific research center

Colleges and Universities ：
1. Laboratory of Structural Biology Tsinghua University（Academician Zihe Rao's Laboratory）
2. Institute of Biochemical Engineering, Tsinghua University
3. Fudan University State Key Laboratory of Genetic Engineering
4. Institutes of Biomedical Sciences, Fudan University(IBS)
5. School of Pharmacy, Fudan University
6. East China University of Science and Technology
7. Guangdong Pharmaceutical University
8. Institute of viruses of Wuhan University.
9. College of Medicine Wuhan University
10. College of Life Science, HuaZhong Normal University
11. South China Normal University
12. Bioengineering Institute of Jinan University
13. Northwest University National Engineering Research Center for Miniaturized Detection System
14. State Key Laboratory of Agricultural Microbiology(AML), Huazhong Agricultural University
15.Dalian Nationalities University
16.Hefei University of Technology
17.Tianjin University of Science&Technology
18.Shantou University Medical College
19.Guangzhou University of Chinese Medicine
20. Zhejiang Normal University
21. China Pharmaceutical University
22. Zhejiang University
23. Fujian Medical University
24. Harbin Institute of Technology
25.College of Life Science, Shandong University
26.College of Medicine, Shandong University
27.The Key Laboratory of Gene Engineering of Ministry of Education
28.Yangzhou University
29.Suzhou institute of Southeast University

Enterprise Glories and Intellectual properties
Approved by Guangdong Province as an enterprise of high-tech in 2008
Supported by Innovation Fund of China
Supported by Technology Innovation Fund of Guangzhou.
Has one item of national invention patent
Has ten items of national utility model patents
Has two items of exterior design patent
Have registered the trademark “JNBIO” and “聚能生物” in State Trademark Office