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1. SynBBB 3D Blood Brain Barrier Model – Real-time visualization of cellular and barrier functionality SynVivo’s SynBBB 3D blood brain barrier model recreates the in vivo microenvironment by emulating a histological slice of brain tissue cells in communication with endothelial cells across the blood brain barrier (BBB). Shear-induced endothelial cell tight junctions, which cannot be achieved in the Transwell? model, are easily achieved in the SynBBB model using physiological fluid flow. Formation of tight changes can be measured using biochemical or electrical analysis (assessing changes in electrical resistance) with the SynVivo Cell Impedance Analyzer. Interactions between brain tissue cells and endothelial cells are readily visualized in the SynBBB assay. Transwell models do not allow real-time visualization of these cellular interactions, which are critical for understanding of the BBB microenvironment. SynBBB is the only in vitro BBB model that allows: ●Accurate in vivo hemodynamic shear stress ●Real-time visualization of cellular and barrier functionality ●Significant reduction in cost and time ●Robust and easy to use protocols The SynBBB system is a highly versatile platform for investigation of: Tight junction proteins: Determine the levels of tight junction proteins namely zonula occludens, claudins and occludins which regulate the BBB. Transporter proteins: Analyze functionality of transporter proteins (e.g. Pgp) in normal and dysfunctional BBB. Drug permeability: Evaluate real-time permeability of therapeutics and small molecules across the endothelium of the BBB. Inflammation: Understand the underlying mechanisms of inflammatory responses on the regulation of the BBB. Cell migration: Visualize and quantify in real-time migration of immune cells across the BBB. Omic changes: Perform genomic, proteomic and metabolic analysis on normal and dysfunctional BBB. Neurotoxicity: Analyze toxicity effects of chemical, biological and physical agents on the cells of the BBB. Neuro-oncology: Investigate effects of the tumor cells on the BBB. Depending on your research needs you can select from the “basic” SynBBB model or a “TEER-compatible” SynBBB configuration. TEER Compatible SynBBB Configuration with the SynVivo Cell Impedance Analyzer Analyze experiments using real-time trans-endothelial electrical resistance (TEER) including real-time imaging, biochemical and molecular biology methodologies.
2. SynTumor 3D Cancer Model – Recreating the tumor microenvironment SynTumor is a 3D tissue model for real-time visualization and quantitative assessment of cell-cell and cell-drug interactions in a physiologically and morphologically realistic tumor microenvironment. The system enables (a) circulation in the microvasculature, (b) transport across the vessel walls, and (c) delivery to the tumors. Starting with scans of vascular networks incorporated with interstitial and tissue/tumor spaces, the SynTumor 3D tissue model creates an in-vitro tumor microenvironment akin to a viable histological slice. The SynTumor 3D Cancer model has the following benefits: ●Side by side architecture enables quantitative real time visualization ●Physiological leaky vasculature with engineered porous structures ●Morphologically realistic in vivo based architecture ●Physiologically realistic convective and diffusive transport ●Microfluidic platform with ultra-low consumable volumes Depending on your research needs you can select from the “idealized” or “microvascular” SynTumor 3D Cancer Model configuration.
3. SynRAM 3D Inflammation Model – Visualize Rolling, Adhesion and Migration in a Single Assay The SynRAM? 3D Inflammation Model from SynVivo has been developed to study the entire inflammation pathway in a realistic and dynamic environment. By recreating a histological slice of co-cultured tissue and/or tumor cells with a lumen of endothelial cells, the SynVivo platform delivers a physiologically realistic model including flow and shear in a platform and enables real-time tracking of rolling, adhesion and migration processes. This model has been successfully validated against in vivo studies showing excellent correlation with rolling velocities, adhesion patterns and migratory processes (Lamberti et al 2014, Soroush et al 2016). The SynRAM 3D inflammation model provides a realistic testing environment including: ●Physiological shear stress within a microvascular environment ●In vivo like vascular morphology with fully enclosed lumen ●Co-culture capability for cell-cell interactions ●Quantitative real-time rolling, adhesion, and migration data from a single experiment SynRAM enables assessment of cellular interactions comprising of rolling, adhesion and migration through multiple cellular layers in one experiment, in real-time, and represents data closely correlated with in vivo results. SynRAM’s innovative design overcomes the current limitations inherent in flow chambers or Transwell chamber based assays. Current flow chamber designs are oversimplified, lack the scale and geometry of the microenvironment and cannot model transmigration. Similarly, Transwell chambers do not account for fluid shear and size/topology observed in vivo, the end point measurements of migration are not reproducible and do not provide real-time visualization. SynVivo’s proprietary chip designs range from complex in vivo derived microvascular networks (obtained from digitized images) to produce realistic cellular makeup and vascular morphology resulting in varying shear and flow conditions, to simplified idealized networks designed to reproduce the cellular makeup
4. SynTox 3D Toxicology Model – Organ Specific Physiological Responses SynTox is the only commercially available 3D toxicology model with real-time optical monitoring and multi-compartment, multi-cellular architecture and low reagent requirements. Other benefits of this platform are: Physiologically realistic morphological, fluidic and 3D cellular conditions Universal platform with architecture specific of desired organ Significant reduction in cost and time Robust and easy to use protocols Compatible with standard analytical instruments for both on chip and off chip assays including omic methodologies for systems biology and bioinformatic analysis SynTox 3D Toxicology Model recreates the in vivo micro-environment by emulating a histological slice operating in an in vitro Environment. Current in vitro platforms are poor predictors of in vivo safety, efficacy and pharmacokinetics of therapeutics owing to significant difference in the test conditions compared to physiological conditions observed in vivo. Current in vitro models routinely utilize 2D monolayers or 3D aggregates of cells under static conditions for studying drug toxicity. These models fail to reproduce in vivo physiological features such as morphological size, physiological blood flow and cellular (biological) make-up of the specific organs being investigated. Other microfluidic models employ a membrane-based top-bottom two-compartment architecture, inherently limiting key desired features such as real-time visualization and the ability to simultaneous analyze multi-cellular cultures.
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