System Overview

The Liberty Blue™ Automated Microwave Peptide Synthesizer is the best selling peptide synthesizer in the world. It features a 4-minute cycle time along with a 90% solvent reduction based on High Efficiency Solid Phase Peptide synthesis (HE-SPPS) developed in 2013. This system is utilized in hundreds of laboratories worldwide and provides unparalleled peptide quality based on its unique methodology and use of microwave energy. The Liberty Blue features the latest in engineering for fluidic deliveries, true internal temperature feedback control, and software control with 21 CFR Part 11 compliance.

Awards

2014 R&D 100 Award Winner.

Unique Chemistry

• CarboMAX™ coupling chemistry (patented)
• Microwave deprotection and coupling (patented)

Features

4 min cycle time

90% waste reduction (HE-SPPS)

Flex-Add™ critical reagent delivery system (patented)

True Internal fiber-optic temperature control

0.005 - 5 mmol scale range

27 amino acid positions

Integrated Camera (optional)

High-throughput upgrade options

Speed

An Incredibly Fast Peptide Synthesizer
4 min cycle times (HE-SPPS)
Access to peptides in less than a day
Optional automated synthesis of up to 24 peptides
 

CarboMAX

The best coupling method for peptide synthesis
The fastest and most complete coupling
Unmatched low level of epimerization for all 20 amino acids
Highest purities with patented microwave deprotection and coupling (US7393920, US7582728, US8058393, CA2471687)
Simplify synthesis by eliminating the need for time consuming method screening 

Flex-Add

The best way to deliver critical reagents
Infinitely variable – deliver whatever volume you want (unlike sample loops)
No priming ever
No washing and less complex than syringe pumps
 

Solvent Reduction

Unprecedented 90% solvent reduction
Judicious use of solvents and reagents from optimized washing and synthetic protocols
Superior system design minimizes calibration, cleaning, and maintenance needs
 

Software

The most advanced software for simple and flexible control
Automated programming of standard and complex peptides (branched, cyclized, disulfide bonding)
21 CFR Part 11 compliance including full run history and method reports
Integrated real-time camera into microwave cavity
 

Purity

We’ve raised the standard for peptide purity
Liberty Blue systems deliver unparalleled peptide quality and synthesis success. From the fundamental principle of using controlled microwave energy to heat the reaction and not the vessel, to the innovative design of hardware, software and speciality chemicals, to the focus on efficient systems for loading, delivery, monitoring and removal, everything contributes to optimal chemistry for the highest purity and yields.
View Published Data
 

Applications 

Synthesize standard and complex peptides
Branched Peptides
Cyclized Peptides
Disulfide Bonding
Glycopeptides (N/O-linked)
High Throughput Synthesis
N-Methyl Peptides
Peptide Thioesters
Peptoids
Phospho-peptides
PNA

Learn more at http://cem.com/liberty-blue/