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產(chǎn)品名稱

IITZ-01

產(chǎn)品貨號(hào)

Axon 2933 CAS [1807988-47-1] MF C26H23FN8OMW 482.51 Purity: 99% Soluble in DMSO Recently added

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

IITZ-01

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2933

CAS [1807988-47-1]

MF C26H23FN8O
MW 482.51

Purity: 99%
Soluble in DMSO

Recently added

IITZ-01

Description

IITZ-01 is a potent lysosomotropic autophagy inhibitor which has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo. Screening against the growth of cancer cell lines MCF-7, MDAMB-231, PC-3, DU-145, HT-29 and HGC-27 gave IC50 values of 1.0 μM, 1.5 μM, 0.8 μM, 1.0 μM, 1.1 μM, 0.8 μM, respectively.

GJ Kumar et al. Synthesis and characterization of new s-triazine bearing benzimidazole and benzothiazole derivatives as anticancer agents. Medicinal Chemistry Research. December 2015, Volume 24, Issue 12, pp 3991–4001.

L Guntuku et al. IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo. Oncogene. 2019 Jan;38(4):581-595.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Diabetes & Metabolism Autophagy

Potent lysosomotropic autophagy inhibitor

Chemical name

N2-(4-(1H-Benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine

Parent CAS No.

[1807988-47-1]

產(chǎn)品資料

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