| 產(chǎn)品名稱 | NRX 194204 - IRX4204 | NRX 4204 | VTP 194204 | AGN 194204 | AGN 4204 |
| 產(chǎn)品貨號 | Axon 2408 CAS [220619-73-8] MF C24H32O2MW 352.51 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Highly potent and specific RXR agonist (Kd values 0.4 nM, 3.6 nM, and 3.8 nM for RXRα, RXRβ, and RXRγ, respectively) devoid of any RAR activity (Kd values >30 μM for RARα, RARβ, and RARγ). NRX 194204 blocked the ability of lipopolysaccharide and TNFα to induce the release of nitric oxide and IL6 and the degradation of IKBα in RAW264.7 macrophage-like cells. NRX194204 prevents carcinogenesis in both the lung and mammary gland, and enhances the ability of ligands for PPARs or cytotoxic drugs, including cisplatin and 5-flurouracil, to inhibit proliferation and induce apoptosis in breast and pancreatic cancer cell lines. KEYWORDS: NRX 194204 | RXR agonist | NRX 4204 | VTP 194204 | AGN 194204 | AGN 4204 | NRX4204;NRX-4204; IRX 4204; IRX-4204 | NRX194204; NRX-194204 | VTP194204; VTP-194204 | AGN194204; AGN-194204 | AGN4204; AGN-4204 | CAS [220619-73-8] | Retinoic Acid | Retinoic Acid (RXR) | devoid | RAR | carcinogenesis | Agonist | Receptors |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
NRX 194204 - IRX4204 | NRX 4204 | VTP 194204 | AGN 194204 | AGN 4204Axon 2408 CAS [220619-73-8] MF C24H32O2
DescriptionHighly potent and specific RXR agonist (Kd values 0.4 nM, 3.6 nM, and 3.8 nM for RXRα, RXRβ, and RXRγ, respectively) devoid of any RAR activity (Kd values >30 μM for RARα, RARβ, and RARγ). NRX 194204 blocked the ability of lipopolysaccharide and TNFα to induce the release of nitric oxide and IL6 and the degradation of IKBα in RAW264.7 macrophage-like cells. NRX194204 prevents carcinogenesis in both the lung and mammary gland, and enhances the ability of ligands for PPARs or cytotoxic drugs, including cisplatin and 5-flurouracil, to inhibit proliferation and induce apoptosis in breast and pancreatic cancer cell lines. KEYWORDS: NRX 194204 | RXR agonist | NRX 4204 | VTP 194204 | AGN 194204 | AGN 4204 | NRX4204;NRX-4204; IRX 4204; IRX-4204 | NRX194204; NRX-194204 | VTP194204; VTP-194204 | AGN194204; AGN-194204 | AGN4204; AGN-4204 | CAS [220619-73-8] | Retinoic Acid | Retinoic Acid (RXR) | devoid | RAR | carcinogenesis | Agonist | Receptors
Highly potent and specific RXR agonist devoid of any RAR activity
Chemical name(2E,4E)-3-Methyl-5-((1S,2S)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl)penta-2,4-dienoic acid Parent CAS No.[220619-73-8] |
| 產(chǎn)品資料 |
