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產(chǎn)品名稱

CC-885

產(chǎn)品貨號(hào)

Axon 2645 CAS [1010100-07-8] MF C22H21ClN4O4MW 440.88 Purity: 99% Soluble in DMSO Description Cereblon (CRBN) modulator with potent anti-tumour activity which is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1. CC-885 exhibits potent anti-proliferative activity in patient-derived acute myeloid leukaemia (AML) tumour cell lines. KEYWORDS:?CC-885 | supplier | Cereblon (CRBN) modulator | CC885 | CAS [1010100-07-8] | Ubitquitin | signaling | E3 ligase | GSPT1 | CRL4 | DDB1 | CUL4 | AML | myeloid leukaemia

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

CC-885

Based on 2 reference(s) in Google Scholar 10 10 2

Axon 2645

CAS [1010100-07-8]

MF C22H21ClN4O4
MW 440.88

Purity: 99%
Soluble in DMSO

CC-885

Description

Cereblon (CRBN) modulator with potent anti-tumour activity which is mediated through the cereblon-dependent ubiquitination and degradation of the translation termination factor GSPT1. CC-885 exhibits potent anti-proliferative activity in patient-derived acute myeloid leukaemia (AML) tumour cell lines.

KEYWORDS:?CC-885 | supplier | Cereblon (CRBN) modulator | CC885 | CAS [1010100-07-8] | Ubitquitin | signaling | E3 ligase | GSPT1 | CRL4 | DDB1 | CUL4 | AML | myeloid leukaemia

T Ito et al. Cereblon and its downstream substrates as molecular targets of immunomodulatory drugs. Int J Hematol. 2016 Sep;104(3):293-9.

ME Matyskiela et al. A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Nature. 2016 Jul 14;535(7611):252-7.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Immunology Ubiquitin Ubiquitin

Cereblon (CRBN) modulator with potent anti-tumour activity

Chemical name

1-(3-chloro-4-methylphenyl)-3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)urea

Parent CAS No.

[1010100-07-8]

產(chǎn)品資料

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