| 產(chǎn)品名稱 | CDN1163 |
| 產(chǎn)品貨號 | Axon 2684 CAS [892711-75-0] MF C20H20N2O2MW 320.39 Purity: 100% Soluble in DMSO Description CDN1163 is an allosteric activator of sarco/endoplasmic reticulum Ca2+-ATPase 2b (SERCA2b) and markedly lowered fasting blood glucose, improved glucose tolerance, and ameliorated hepatosteatosis in a genetic model of insulin resistance and type 2 diabetes (ob/ob mice). CDN1163 treatment significantly reduced the hepatic expression of genes involved in gluconeogenesis and lipogenesis, attenuated ER stress response and ER stress-induced apoptosis, and improved mitochondrial biogenesis. Moreover, CDN1163 increased ER calcium content, rescued neurons from ER stress-induced cell death in vitro, and showed significant efficacy in the rat 6-hydroxydopamine (6-OHDA) model of Parkinson's disease. KEYWORDS: CDN1163 | supplier | SERCA activator | CDN 1163 | CDN-1163 | CAS [892711-75-0] | ATP | ATPase (Ca2+) | Activator | Enzymes | SERCA | 6-OHDA | Obesitas | Diabetes | Metabolic Disorder | Metabolic Dysfunction | ER Stress | Parkinson's Disease |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
CDN1163Axon 2684 CAS [892711-75-0] MF C20H20N2O2
DescriptionCDN1163 is an allosteric activator of sarco/endoplasmic reticulum Ca2+-ATPase 2b (SERCA2b) and markedly lowered fasting blood glucose, improved glucose tolerance, and ameliorated hepatosteatosis in a genetic model of insulin resistance and type 2 diabetes (ob/ob mice). CDN1163 treatment significantly reduced the hepatic expression of genes involved in gluconeogenesis and lipogenesis, attenuated ER stress response and ER stress-induced apoptosis, and improved mitochondrial biogenesis. Moreover, CDN1163 increased ER calcium content, rescued neurons from ER stress-induced cell death in vitro, and showed significant efficacy in the rat 6-hydroxydopamine (6-OHDA) model of Parkinson's disease. KEYWORDS: CDN1163 | supplier | SERCA activator | CDN 1163 | CDN-1163 | CAS [892711-75-0] | ATP | ATPase (Ca2+) | Activator | Enzymes | SERCA | 6-OHDA | Obesitas | Diabetes | Metabolic Disorder | Metabolic Dysfunction | ER Stress | Parkinson's Disease
Allosteric Activator of SERCA2b
Chemical name4-Isopropoxy-N-(2-methylquinolin-8-yl)benzamide Parent CAS No.[892711-75-0] |
| 產(chǎn)品資料 |
