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產(chǎn)品名稱

KD025 - SLx-2119

產(chǎn)品貨號(hào)

Axon 2780 CAS [911417-87-3] MF C26H24N6O2MW 452.51 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description KD025 is a selective, ATP-competitive inhibitor of human ROCK2 (IC50 value of 105 nM) with minimal effects on human ROCK1 (IC50 value of 24 μM). KEYWORDS: KD025 | supplier | ROCK2 inhibitor | SLx-2119 | KD 025 | KD-025 | SLx 2119 | SLx2119 | CAS [911417-87-3] | Non Selective (Phosphorylation Substrates) | ROCK | Inhibitor | Enzymes | Adipogenesis | Obesitas | 3T3-L1

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

KD025 - SLx-2119

Based on 10 reference(s) in Google Scholar 8 10 10

Axon 2780

CAS [911417-87-3]

MF C26H24N6O2
MW 452.51

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

KD025

Description

KD025 is a selective, ATP-competitive inhibitor of human ROCK2 (IC50 value of 105 nM) with minimal effects on human ROCK1 (IC50 value of 24 μM).

KEYWORDS: KD025 | supplier | ROCK2 inhibitor | SLx-2119 | KD 025 | KD-025 | SLx 2119 | SLx2119 | CAS [911417-87-3] | Non Selective (Phosphorylation Substrates) | ROCK | Inhibitor | Enzymes | Adipogenesis | Obesitas | 3T3-L1

M Boerma et al. Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin. Blood Coagul Fibrinolysis. 2008 Oct;19(7):709-18.

DTV Diep et al. Anti-adipogenic effects of KD025 (SLx-2119), a ROCK2-specific inhibitor, in 3T3-L1 cells. Sci Rep. 2018 Feb 6;8(1):2477.

JH Lee et al. Selective ROCK2 Inhibition In Focal Cerebral Ischemia. Ann Clin Transl Neurol. 2014 Jan 1;1(1):2-14.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Diabetes & Metabolism Pain & Inflammation ROCK TGF-β EC 2.7.11.1

Selective ATP-competitive inhibitor of ROCK2

Chemical name

2-(3-(4-(1H-Indazol-5-ylamino)quinazolin-2-yl)phenoxy)-N-isopropylacetamide

Parent CAS No.

[911417-87-3]

產(chǎn)品資料

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