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產(chǎn)品名稱

MBQ-167

產(chǎn)品貨號

Axon 2777 CAS [2097938-73-1] MF C22H18N4MW 338.41 Purity: 98% Soluble in DMSO Description MBQ-167 is an effective Rac and Cdc42 inhibitor with IC50 values of 78 nM and 103 nM, respectively. MBQ-167 significantly decreases Rac and Cdc42 downstream effector p21-activated kinase (PAK) signaling and the activity of STAT3, without affecting Rho, MAPK, or Akt activities. MBQ-167 also inhibits breast cancer cell migration, viability, and mammosphere formation. KEYWORDS: MBQ-167 | supplier | Rac/Cdc42 inhibitor | MBQ167 | MBQ 167 | CAS [2097938-73-1] | Cytoskeleton | Rac | CDC42 | Inhibitor | Enzymes | PAK | STAT3 | Breast Cancer

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

MBQ-167

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2777

CAS [2097938-73-1]

MF C22H18N4
MW 338.41

Purity: 98%
Soluble in DMSO

MBQ-167

Description

MBQ-167 is an effective Rac and Cdc42 inhibitor with IC50 values of 78 nM and 103 nM, respectively. MBQ-167 significantly decreases Rac and Cdc42 downstream effector p21-activated kinase (PAK) signaling and the activity of STAT3, without affecting Rho, MAPK, or Akt activities. MBQ-167 also inhibits breast cancer cell migration, viability, and mammosphere formation.

KEYWORDS: MBQ-167 | supplier | Rac/Cdc42 inhibitor | MBQ167 | MBQ 167 | CAS [2097938-73-1] | Cytoskeleton | Rac | CDC42 | Inhibitor | Enzymes | PAK | STAT3 | Breast Cancer

T Humphries-Bickley et al. Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer. Mol Cancer Ther. 2017 May;16(5):805-818.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Cdc42 JAK-STAT Rac

Dual Rac and Cdc42 inhibitor

Chemical name

9-Ethyl-3-(5-phenyl-1H-1,2,3-triazol-1-yl)-9H-carbazole

Parent CAS No.

[2097938-73-1]

產(chǎn)品資料

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