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產(chǎn)品名稱

ML 311

產(chǎn)品貨號

Axon 2823 CAS [315698-17-0] MF C23H24F3N3OMW 415.45 Purity: 99% Soluble in DMSO Description Potent and selective inhibitor of the protein-protein interaction of Mcl-1 and Bim with an IC50 value of 0.31 μM for Mcl-1. ML 311 displayed significant activity in a number of cell lines, with EC50 values in the range of 0.3–15 M. Useful tool for studying lymphoid tumorigenesis and to demonstrate the potential for using this strategy in therapies intended to bypass apoptosis resistance pathways that are activated in drug-resistant tumors. Keywords: ML 311 | supplier | Mcl-1-Bim interaction inhibitor | ML311 | ML-311 | CAS [315698-17-0] | Non Selective | Mcl-1 | Inhibitor | Proteins | Lymphoid Tumorigenesis | Bim

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

ML 311

Based on 3 reference(s) in Google Scholar 8 10 3

Axon 2823

CAS [315698-17-0]

MF C23H24F3N3O
MW 415.45

Purity: 99%
Soluble in DMSO

ML 311

Description

Potent and selective inhibitor of the protein-protein interaction of Mcl-1 and Bim with an IC50 value of 0.31 μM for Mcl-1. ML 311 displayed significant activity in a number of cell lines, with EC50 values in the range of 0.3–15 M. Useful tool for studying lymphoid tumorigenesis and to demonstrate the potential for using this strategy in therapies intended to bypass apoptosis resistance pathways that are activated in drug-resistant tumors.

Keywords: ML 311 | supplier | Mcl-1-Bim interaction inhibitor | ML311 | ML-311 | CAS [315698-17-0] | Non Selective | Mcl-1 | Inhibitor | Proteins | Lymphoid Tumorigenesis | Bim

T Bannister et al. ML311: A Small Molecule that Potently and?Selectively Disrupts the Protein-Protein Interaction of Mcl-1 and Bim: A Probe for Studying Lymphoid Tumorigenesis. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2012 Apr 16

DJ Richard et al. Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker. Bioorg Med Chem. 2013 Nov 1;21(21):6642-9.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Mcl-1

Potent and selective inhibitor of the protein-protein interaction of Mcl-1 and Bim

Chemical name

7-((4-Ethylpiperazin-1-yl)(4-(trifluoromethyl)phenyl)methyl)quinolin-8-ol

Parent CAS No.

[315698-17-0]

產(chǎn)品資料

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