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產(chǎn)品名稱

BQU 57

產(chǎn)品貨號

Axon 2397 CAS [1637739-82-2] MF C16H13F3N4OMW 334.30 Purity: 99% Soluble in DMSO Description Inhibitor of the RAS-like small GTPases RalA and RalB (Kd value 7.7 μM for RalB-GDP; IC50 values 2.0 mM and 1.3 mM for growth inhibition in H358 and H2122 tumor xenografts, respectively). BQU57 shows selectivity for Ral relative to the GTPases Ras and RhoA. Mechanistically, BQU-57 inhibits the binding of Ral proteins in their GDP-bound form to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines. Close analogue of RBC 8 (Axon 2396) References Certificates Categories Extra info C. Yan et al. Small molecules inhibit the RAS-like small GTPases RALA and RALB. Cancer Discov. 2014 Nov;4(11):1251. ? C. Yan et al. Discovery and characterization of small molecules that target the GTPase Ral. Nature. 2014 Nov 20;515(7527):443-7. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology MAPK EC 3.6.5.2 RalA RalB Inhibitor of the RAS-like small GTPases RalA and RalB Chemical name 6-amino-1,3-dimethyl-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile Parent CAS No. [1637739-82-2] Order Size Unit Price Stock 5 mg €125.00 In Stock

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現(xiàn)貨詢價(jià)，電話：010-67529703

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產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

BQU 57

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2397

CAS [1637739-82-2]

MF C16H13F3N4O
MW 334.30

Purity: 99%
Soluble in DMSO

BQU 57

Description

Inhibitor of the RAS-like small GTPases RalA and RalB (Kd value 7.7 μM for RalB-GDP; IC50 values 2.0 mM and 1.3 mM for growth inhibition in H358 and H2122 tumor xenografts, respectively). BQU57 shows selectivity for Ral relative to the GTPases Ras and RhoA. Mechanistically, BQU-57 inhibits the binding of Ral proteins in their GDP-bound form to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines. Close analogue of RBC 8 (Axon 2396)

C. Yan et al. Small molecules inhibit the RAS-like small GTPases RALA and RALB. Cancer Discov. 2014 Nov;4(11):1251.

C. Yan et al. Discovery and characterization of small molecules that target the GTPase Ral. Nature. 2014 Nov 20;515(7527):443-7.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology MAPK EC 3.6.5.2 RalA RalB

Inhibitor of the RAS-like small GTPases RalA and RalB

Chemical name

6-amino-1,3-dimethyl-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

Parent CAS No.

[1637739-82-2]

產(chǎn)品資料

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