| 產(chǎn)品名稱 | RBC 8 |
| 產(chǎn)品貨號 | Axon 2396 CAS [361185-42-4] MF C25H20N4O3MW 424.45 Purity: 99% Soluble in DMSO Description Inhibitor of the RAS-like small GTPases RalA and RalB (IC50 values 3.5 μM and 3.4 μM for growth inhibition in H2122 and?H358 tumor xenografts, respectively). RBC8 shows selectivity for Ral relative to the GTPases Ras and RhoA. Mechanistically, RBC8 inhibits the binding of Ral proteins in their GDP-bound form to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines. Close analogue of BQU 57 (Axon 2397) KEYWORDS: RBC 8 | supplier | RalA/B inhibitor | RBC8 | CAS [361185-42-4] | GTP | RalA | RalB | Inhibitor | Enzymes | Ral | Ras-like | GTPase | xenograft | RALBP1 | GDP | GTP | switch | cancer | fibroblasts |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
RBC 8Axon 2396 CAS [361185-42-4] MF C25H20N4O3
DescriptionInhibitor of the RAS-like small GTPases RalA and RalB (IC50 values 3.5 μM and 3.4 μM for growth inhibition in H2122 and?H358 tumor xenografts, respectively). RBC8 shows selectivity for Ral relative to the GTPases Ras and RhoA. Mechanistically, RBC8 inhibits the binding of Ral proteins in their GDP-bound form to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines. Close analogue of BQU 57 (Axon 2397) KEYWORDS: RBC 8 | supplier | RalA/B inhibitor | RBC8 | CAS [361185-42-4] | GTP | RalA | RalB | Inhibitor | Enzymes | Ral | Ras-like | GTPase | xenograft | RALBP1 | GDP | GTP | switch | cancer | fibroblasts
Inhibitor of the RAS-like small GTPases RalA and RalB
Chemical name6-amino-4-(2,5-dimethoxyphenyl)-3-(naphthalen-2-yl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile Parent CAS No.[361185-42-4] |
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