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產(chǎn)品名稱

PLX 4032 - RG 7204 | Vemurafenib | RO 5185426

產(chǎn)品貨號

Axon 1624 CAS [918504-65-1] MF C23H18ClF2N3O3SMW 489.92 Purity: 98% Soluble in DMSO Description Selective inhibitor of protein kinase, targeting B-Raf (V600E) (IC50: 44 nM); PLX4032 has been shown to cause programmed cell death in melanoma cell lines; a potential anti-tumor agent under clinical trials References Certificates Categories Extra info G Bollag et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 2010, 467, 596–599. ? PI Poulikakos et al. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 2010, 464, 427-430. ? E Sala et al. BRAF Silencing by Short Hairpin RNA or Chemical Blockade by PLX4032 Leads to Different Responses in Melanoma and Thyroid Carcinoma Cells. Mol. Cancer Res. 2008, 6(5), 751-759. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology MAPK EC 2.7.11.1 RAF B-Raf protein kinase inhibitor Chemical name N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide Parent CAS No. [918504-65-1] Order Size Unit Price Stock 5 mg €75.00 In Stock

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

PLX 4032 - RG 7204 | Vemurafenib | RO 5185426

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 1624

CAS [918504-65-1]

MF C23H18ClF2N3O3S
MW 489.92

Purity: 98%
Soluble in DMSO

PLX 4032

Description

Selective inhibitor of protein kinase, targeting B-Raf (V600E) (IC50: 44 nM); PLX4032 has been shown to cause programmed cell death in melanoma cell lines; a potential anti-tumor agent under clinical trials

G Bollag et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 2010, 467, 596–599.

PI Poulikakos et al. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 2010, 464, 427-430.

E Sala et al. BRAF Silencing by Short Hairpin RNA or Chemical Blockade by PLX4032 Leads to Different Responses in Melanoma and Thyroid Carcinoma Cells. Mol. Cancer Res. 2008, 6(5), 751-759.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology MAPK EC 2.7.11.1 RAF

B-Raf protein kinase inhibitor

Chemical name

N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide

Parent CAS No.

[918504-65-1]

產(chǎn)品資料

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