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產(chǎn)品名稱

Locostatin - UIC 1005

產(chǎn)品貨號

Axon 2590 CAS [90719-30-5] MF C14H15NO3MW 245.27 Purity: 100% Optical purity: Optically pure Soluble in DMSO and Ethanol Description Non-toxic Raf kinase inhibitory protein (RKIP) inhibitor; disrupts the interaction of RKIP, not only with Raf-1 kinase, but also with GRK2; Locostatin is an inhibitor of cell sheet migration and cell growth in an epithelial cell proliferation assay, and it induced T cell anergy by blocking cytokine production after Ag recall. Other evidence suggested that Locostatin’s effects on cytoskeletal structure and migration are caused through mechanisms independent of its binding to RKIP and Raf/MAP kinase signaling. KEYWORDS: Locostatin | supplier | RKIP/Raf inhibitor | UIC 1005 | UIC1005 | (N-crotonyl)-(4S)-isopropyl-2-oxazolidinone | (S)-(+)-4-benzyl-3-crotonyl-2-oxazolidinone | CAS [90719-30-5] | MAPK | MEK | RAF | Inhibitor | PEBP1 | Phosphatidylethanolamine Binding Protein | cell sheet migration | NF-kB | NIK | PKC | GPCR kinase 2

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Locostatin - UIC 1005

Based on 102 reference(s) in Google Scholar 10 10 102

Axon 2590

CAS [90719-30-5]

MF C14H15NO3
MW 245.27

Purity: 100%
Optical purity: Optically pure
Soluble in DMSO and Ethanol

Locostatin

Description

Non-toxic Raf kinase inhibitory protein (RKIP) inhibitor; disrupts the interaction of RKIP, not only with Raf-1 kinase, but also with GRK2; Locostatin is an inhibitor of cell sheet migration and cell growth in an epithelial cell proliferation assay, and it induced T cell anergy by blocking cytokine production after Ag recall. Other evidence suggested that Locostatin’s effects on cytoskeletal structure and migration are caused through mechanisms independent of its binding to RKIP and Raf/MAP kinase signaling.

KT Mc Henry et al. A non-antibacterial oxazolidinone derivative that inhibits epithelial cell sheet migration. Chembiochem. 2002 Nov 4;3(11):1105-11.

AN Shemon et al. Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration. PLoS One. 2009 Jun 24;4(6):e6028.

A Ménoret et al. The oxazolidinone derivative locostatin induces cytokine appeasement. J Immunol. 2009 Dec 1;183(11):7489-96.

AB Beshir et al. Locostatin Disrupts Association of Raf Kinase Inhibitor Protein With Binding Proteins by Modifying a Conserved Histidine Residue in the Ligand-Binding Pocket. For Immunopathol Dis Therap. 2011;2(1):47-58.

Certificate of Analysis
Material Safety Data Sheet

Cell Cycle Regulation Cell Signaling & Oncology CNS NF-κB MAPK PI3K-Akt-mTOR EC 2.7.11.1 RAF

Non-toxic Raf kinase inhibitory protein (RKIP) inhibitor

Chemical name

(S,E)-4-benzyl-3-but-2-enoyloxazolidin-2-one

Parent CAS No.

[90719-30-5]

產(chǎn)品資料

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