| 產(chǎn)品名稱 | BIX 02188 |
| 產(chǎn)品貨號(hào) | Axon 1808 CAS [334951-92-7] MF C26H26N4O2MW 426.51 Purity: 99% Soluble in DMSO Description Selective dual MEK5 kinase inhibitor, with IC50 values of 4.3, 810, 1800, and >6300 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively. References Certificates Categories Extra info RJ Tatake et al. Identification of pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem. Biophys. Res. Comm. 2008, 377(1),?120–125. ? Y Obara and N Nakahata. The signaling pathway leading to extracellular signal-regulated kinase 5 (ERK5) activation via G-proteins and ERK5-dependent neurotrophic effects. Mol. Pharmacol. 2010, 77(1), 10-16.?? ? BA Drew, ME Burowa , BS Beckman. MEK5/ERK5 pathway: The first fifteen years. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2012, 1825 (1), 37-48. ? E. Razumovskaya et al. Inhibition of MEK5 by BIX02188 induces apoptosis in cells expressing the oncogenic mutant FLT3-ITD. Biochem. Biophys. Res. Commun. 2011, 412, 307-312. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Stem Cell MAPK EC 2.7.12.2 ERK MEK MEK5 inhibitor; ERK5 inhibitor Chemical name (Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N-methyl-2-oxoindoline-6-carboxamide Parent CAS No. [334951-92-7] Order Size Unit Price Stock 5 mg €125.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
BIX 02188Axon 1808 CAS [334951-92-7] MF C26H26N4O2
Description
Selective dual MEK5 kinase inhibitor, with IC50 values of 4.3, 810, 1800, and >6300 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.
MEK5 inhibitor; ERK5 inhibitor
Chemical name(Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-N-methyl-2-oxoindoline-6-carboxamide Parent CAS No.[334951-92-7] |
| 產(chǎn)品資料 |
