| 產(chǎn)品名稱 | BIBR 1532 |
| 產(chǎn)品貨號(hào) | Axon 2301 CAS [321674-73-1] MF C21H17NO3MW 331.36 Purity: 99% Soluble in DMSO Description Potent and selective inhibitor of native and recombinant human telomerase (IC50 values of ca. 100 nM), capable of inducing senescence in human cancer cells. BIBR1532 is a mixed-type non-competitive inhibitor of the human telomerase reverse transcriptase and human telomerase RNA components with similar potency primarily by interfering with the processivity of the enzyme. BIBR 1532 defines a novel class of mixed-type non-competitive telomerase inhibitor with mechanistic similarities to non-nucleosidic inhibitors of HIV1 reverse transcriptase. References Certificates Categories Extra info E. Pascolo et al. Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate. J. Biol. Chem. 2002, 277, 15566-15572. ? D.K. Barma et al. Inhibition of telomerase by BIBR 1532 and related analogues. Bioorg. Med. Chem. Lett. 2003, 13, 1333-1336. ? K. Damm et al. A highly selective telomerase inhibitor limiting human cancer cell proliferation. E.M.B.O.J. 2001, 20, 6958-6968. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Immunology RT p53-Tumor Suppression DNA-damage Response EC 2.7.7.49 Telomerase Potent and selective telomerase inhibitor inducing senescence in human cancer cells. Chemical name (E)-2-(3-(Naphthalen-2-yl)but-2-enamido)benzoic acid Parent CAS No. [321674-73-1] Order Size Unit Price Stock 5 mg €70.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
BIBR 1532Axon 2301 CAS [321674-73-1] MF C21H17NO3
DescriptionPotent and selective inhibitor of native and recombinant human telomerase (IC50 values of ca. 100 nM), capable of inducing senescence in human cancer cells. BIBR1532 is a mixed-type non-competitive inhibitor of the human telomerase reverse transcriptase and human telomerase RNA components with similar potency primarily by interfering with the processivity of the enzyme. BIBR 1532 defines a novel class of mixed-type non-competitive telomerase inhibitor with mechanistic similarities to non-nucleosidic inhibitors of HIV1 reverse transcriptase.
Potent and selective telomerase inhibitor inducing senescence in human cancer cells.
Chemical name(E)-2-(3-(Naphthalen-2-yl)but-2-enamido)benzoic acid Parent CAS No.[321674-73-1] |
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