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產(chǎn)品名稱

COTI-2

產(chǎn)品貨號

Axon 2841 CAS [1039455-84-9] MF C19H22N6SMW 366.48 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description COTI-2 is an anti-cancer drug which appears to act both by reactivating mutant p53 and inhibiting the PI3K/AKT/mTOR pathway. Proposed to cause cancer cell death via apoptosis. COTI-2 exhibits potent anti-proliferative activity against a wide variety of human cancer cell lines in vitro (at nanomolar concentrations) and against human tumor xenografts. KEYWORDS: COTI-2 | supplier | p53 activator | COTI2 | COTI 2 | CAS [1039455-84-9] | DNA-RNA | p53 | Activator | Transcription Factors

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

COTI-2

Based on 5 reference(s) in Google Scholar 8 10 5

Axon 2841

CAS [1039455-84-9]

MF C19H22N6S
MW 366.48

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

COTI-2

Description

COTI-2 is an anti-cancer drug which appears to act both by reactivating mutant p53 and inhibiting the PI3K/AKT/mTOR pathway. Proposed to cause cancer cell death via apoptosis. COTI-2 exhibits potent anti-proliferative activity against a wide variety of human cancer cell lines in vitro (at nanomolar concentrations) and against human tumor xenografts.

KY Salim et al. COTI-2, a novel small molecule that is active against multiple human cancer cell lines in vitro and in vivo. Oncotarget. 2016 Jul 5;7(27):41363-41379.

MJ Duffy et al. Mutant p53 as a target for cancer treatment. Eur J Cancer. 2017 Sep;83:258-265.

S Maleki Vareki et al. Novel anti-cancer drug COTI-2 synergizes with therapeutic agents and does not induce resistance or exhibit cross-resistance in human cancer cell lines. PLoS One. 2018 Jan 24;13(1):e0191766.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Signaling & Oncology p53 Transcription Factors p53-Tumor Suppression PI3K-Akt-mTOR TF class 4.3.1

Reactivator of mutant p53

Chemical name

N'-(6,7-Dihydroquinolin-8(5H)-ylidene)-4-(pyridin-2-yl)piperazine-1-carbothiohydrazide

Parent CAS No.

[1039455-84-9]

產(chǎn)品資料

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