| 產(chǎn)品名稱 | TG 003 |
| 產(chǎn)品貨號 | Axon 1765 CAS [719277-26-6] MF C13H15NO2SMW 249.33 Purity: 98% Soluble in DMSO Description Potent and specific inhibitor of Cdc2-like kinase (Clk) family (Ki = 10 nM for mClk1/Sty; IC50 = 15 nM, 20 nM, 200 nM, and > 10 mM for mClk4, mClk1, mClk2, and mClk3, respectively); a valuable tool to dissect the regulatory mechanisms involving serine/arginine-rich protein phosphorylation signaling pathways in vivo, and potential for the therapeutic manipulation of abnormal splicing References Certificates Categories Extra info M Muraki et al. Manipulation of alternative splicing by a newly developed inhibitor of Clks. J Biol Chem. 2004, 279(23), 24246-24254. ? A Nishida et al. Chemical treatment enhances skipping of a mutated exon in the dystrophin gene. Nature Commun. 2011, 2, 308. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology EC 2.7.12.1 CLK Inhibitor of Cdc2-like kinase (Clk) family Chemical name (Z)-1-(3-ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one Parent CAS No. [719277-26-6; 300801-52-9(mix E/Z); 1164521-02-1 (E)] Order Size Unit Price Stock 10 mg €115.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
TG 003Axon 1765 CAS [719277-26-6] MF C13H15NO2S
Description
Potent and specific inhibitor of Cdc2-like kinase (Clk) family (Ki = 10 nM for mClk1/Sty; IC50 = 15 nM, 20 nM, 200 nM, and > 10 mM for mClk4, mClk1, mClk2, and mClk3, respectively); a valuable tool to dissect the regulatory mechanisms involving serine/arginine-rich protein phosphorylation signaling pathways in vivo, and potential for the therapeutic manipulation of abnormal splicing
Inhibitor of Cdc2-like kinase (Clk) family
Chemical name(Z)-1-(3-ethyl-5-methoxybenzo[d]thiazol-2(3H)-ylidene)propan-2-one Parent CAS No.[719277-26-6; 300801-52-9(mix E/Z); 1164521-02-1 (E)] |
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