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產(chǎn)品名稱

TMS - Trans-2,3',4,5'-tetramethoxystilbene

產(chǎn)品貨號

Axon 2628 CAS [24144-92-1] MF C18H20O4MW 300.35 Purity: 99% Soluble in DMSO Description CYP1B1 inhibitor (IC50 values 6 nM, 300 nM, and 3100 nM for inhibition of CYP1B1, CYP1A1, and CYP1A2, resp.), that potentiates the inhibition of cell growth and induces apoptosis in human cancer cells. Moreover, TMS is a useful compound for characterizing the enzymatic properties of CYP1B1 and its contribution to hypertension and associated pathophysiology. KEYWORDS:?TMS | supplier | CYP1B1 inhibitor | Trans-2,3',4,5'-tetramethoxystilbene | tetramethoxystilbene | CAS [24144-92-1] | Cytochrome P450 | Aryl hydrocarbon hydroxylase | cell growth | apoptosis | cancer | hypertension | cardiovascular

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

TMS - Trans-2,3',4,5'-tetramethoxystilbene

Based on 185 reference(s) in Google Scholar 8 10 185

Axon 2628

CAS [24144-92-1]

MF C18H20O4
MW 300.35

Purity: 99%
Soluble in DMSO

TMS

Description

CYP1B1 inhibitor (IC50 values 6 nM, 300 nM, and 3100 nM for inhibition of CYP1B1, CYP1A1, and CYP1A2, resp.), that potentiates the inhibition of cell growth and induces apoptosis in human cancer cells. Moreover, TMS is a useful compound for characterizing the enzymatic properties of CYP1B1 and its contribution to hypertension and associated pathophysiology.

S Kim et al. Design, synthesis, and discovery of novel trans-stilbene analogues as potent and selective human cytochrome P450 1B1 inhibitors. J Med Chem. 2002 Jan 3;45(1):160-4.

KA Nam et al. Resveratrol analog, 3,5,2',4'-tetramethoxy-trans-stilbene, potentiates the inhibition of cell growth and induces apoptosis in human cancer cells. Arch Pharm Res. 2001 Oct;24(5):441-5.

KU Malik et al. Contribution of cytochrome P450 1B1 to hypertension and associated pathophysiology: a novel target for antihypertensive agents. Prostaglandins Other Lipid Mediat. 2012 Aug;98(3-4):69-74.

Certificate of Analysis
Material Safety Data Sheet

Cardiovascular Cell Signaling & Oncology Diabetes & Metabolism EC 1.14.14.1 Cytochrome P450

CYP1B1 inhibitor that induces apoptosis in human cancer cells

Chemical name

(E)-4,5'-(ethene-1,2-diyl)bis(1,3-dimethoxybenzene)

Parent CAS No.

[24144-92-1]

產(chǎn)品資料

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