| 產(chǎn)品名稱 | SPHINX31 |
| 產(chǎn)品貨號(hào) | Axon 2714 CAS [1818389-84-2] MF C27H24F3N5O2MW 507.51 Purity: 99% Soluble in DMSO Description SPHINX31 is a highly potent, selective, and cell active SRPK1 inhibitor (IC50 value of 6 nM). Treatment with this inhibitor inhibited SRPK1 activity and phosphorylation of serine/arginine splicing factor 1 (SRSF1), resulting in alternative splicing of VEGF-A from pro-angiogenic to antiangiogenic isoforms. This property resulted in potent inhibition of blood vessel growth in models of choroidal angiogenesis in vivo. KEYWORDS: SPHINX31 | supplier | SRPK1 inhibitor | SPHINX 31 | SPHINX-31 | CAS [1818389-84-2] | DNA-RNA | SRPK | Inhibitor | Enzymes | Neovascular Eye Disease | VEGF | SRSF1 |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
SPHINX31Axon 2714 CAS [1818389-84-2] MF C27H24F3N5O2
DescriptionSPHINX31 is a highly potent, selective, and cell active SRPK1 inhibitor (IC50 value of 6 nM). Treatment with this inhibitor inhibited SRPK1 activity and phosphorylation of serine/arginine splicing factor 1 (SRSF1), resulting in alternative splicing of VEGF-A from pro-angiogenic to antiangiogenic isoforms. This property resulted in potent inhibition of blood vessel growth in models of choroidal angiogenesis in vivo. KEYWORDS: SPHINX31 | supplier | SRPK1 inhibitor | SPHINX 31 | SPHINX-31 | CAS [1818389-84-2] | DNA-RNA | SRPK | Inhibitor | Enzymes | Neovascular Eye Disease | VEGF | SRSF1
Potent and selective inhibitor of SRPK1 kinase activity
Chemical nameN-(2-(4-(Pyridin-2-ylmethyl)piperazin-1-yl)-5-(trifluoromethyl)phenyl)-5-(pyridin-4-yl)furan-2-carboxamide Parent CAS No.[1818389-84-2] |
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