| 產(chǎn)品名稱 | BAY 57-1293 - Pritelivir | AIC 316 |
| 產(chǎn)品貨號 | Axon 2266 CAS [348086-71-5] MF C18H18N4O3S2MW 402.49 Purity: 99% Soluble in DMSO Description Potent helicase-primase inhibitor (HPI) effective against herpes simplex virus (HSV) infections with IC50 value of 20 nM for inhibition of the replication of both HSV-1 and HSV-2 in Vero cells, and ED50 value of 0.5 mg/kg for both HSV-1 and HSV-2 in the murine lethal challenge model of disseminated herpes. BAY 57-1293 in vivo was found to be superior compared to all compounds currently used to treat HSV infections, and is active also against acyclovir-resistant mutant strains which carry mutations in the tk or DNA pol genes. References Certificates Categories Extra info J.J. Crute et al. Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease. Nat. Med. 2002, 8, 386-391. ? U.A. Betz et al. Potent in vivo antiviral activity of the herpes simplex virus primase-helicase inhibitor BAY 57-1293. Antimicrob. Agents Chemother. 2002, 46, 1766-1772. ? S. Biswas et al. The helicase primase inhibitor, BAY 57-1293 shows potent therapeutic antiviral activity superior to famciclovir in BALB/c mice infected with herpes simplex virus type 1. Antiviral Res. 2007, 75, 30-35. Certificate of Analysis Material Safety Data Sheet Immunology Helicase-Primase EC 3.6.4.12 Potent helicase-primase inhibitor, effective against herpes simplex virus (HSV) infections Chemical name N-Methyl-N-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide Parent CAS No. [348086-71-5] Order Size Unit Price Stock 5 mg €80.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
BAY 57-1293 - Pritelivir | AIC 316Axon 2266 CAS [348086-71-5] MF C18H18N4O3S2
Description
Potent helicase-primase inhibitor (HPI) effective against herpes simplex virus (HSV) infections with IC50 value of 20 nM for inhibition of the replication of both HSV-1 and HSV-2 in Vero cells, and ED50 value of 0.5 mg/kg for both HSV-1 and HSV-2 in the murine lethal challenge model of disseminated herpes. BAY 57-1293 in vivo was found to be superior compared to all compounds currently used to treat HSV infections, and is active also against acyclovir-resistant mutant strains which carry mutations in the tk or DNA pol genes.
Potent helicase-primase inhibitor, effective against herpes simplex virus (HSV) infections
Chemical nameN-Methyl-N-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide Parent CAS No.[348086-71-5] |
| 產(chǎn)品資料 |
