| 產(chǎn)品名稱 | ASB14780 |
| 產(chǎn)品貨號 | Axon 2578 CAS [1069046-00-9] MF C31H27NO3.C4H11NO3MW 582.69 Purity: 99% Soluble in DMSO Description Potent, orally available inhibitor of cytosolic phospholipase A2α (cPLA2α,?a group IVA phospholipase A2, aka IVA-PLA2) with an IC50 value 0.020 μM in vitro and 0.54 - 0.64 μM in whole blood assay (guinea pig and human, respectively)) with anti-inflammatory efficacy in ear edema and asthma models, and potentially useful for the treatment of nonalcoholic fatty liver diseases, including fatty liver and hepatic fibrosis. ASB14780 markedly attenuated expression of smooth muscle a-actin (a-SMA) protein and the mRNA expression of collagen 1a2, a-SMA, and TGFb1 in the liver, and inhibited the expression of monocyte/macrophage markers. Sold as tromethamine (THAM) salt, as it was used in original publication. KEYWORDS:?ASB14780 | supplier | cPLA2α inhibitor | ASB-14780 | CAS [1069046-00-9] | [1069044-40-1] | Phospholipids | cPLA2 | phospholipase | anti-inflammatory | edema | asthma | pulmonary diseases | fatty liver diseases | hepatic fibrosis | actin | collagen | TGFb1 |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
ASB14780Axon 2578 CAS [1069046-00-9] MF C31H27NO3.C4H11NO3
DescriptionPotent, orally available inhibitor of cytosolic phospholipase A2α (cPLA2α,?a group IVA phospholipase A2, aka IVA-PLA2) with an IC50 value 0.020 μM in vitro and 0.54 - 0.64 μM in whole blood assay (guinea pig and human, respectively)) with anti-inflammatory efficacy in ear edema and asthma models, and potentially useful for the treatment of nonalcoholic fatty liver diseases, including fatty liver and hepatic fibrosis. ASB14780 markedly attenuated expression of smooth muscle a-actin (a-SMA) protein and the mRNA expression of collagen 1a2, a-SMA, and TGFb1 in the liver, and inhibited the expression of monocyte/macrophage markers. Sold as tromethamine (THAM) salt, as it was used in original publication. KEYWORDS:?ASB14780 | supplier | cPLA2α inhibitor | ASB-14780 | CAS [1069046-00-9] | [1069044-40-1] | Phospholipids | cPLA2 | phospholipase | anti-inflammatory | edema | asthma | pulmonary diseases | fatty liver diseases | hepatic fibrosis | actin | collagen | TGFb1
Potent, orally available inhibitor of cPLA2α; antiinflammatory drug
Chemical name3-(3-Phenethyl-1-(4-phenoxyphenyl)-1H-indol-5-yl)propanoic acid tris salt Parent CAS No.[1069044-40-1] |
| 產(chǎn)品資料 |
