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產(chǎn)品名稱

KDM5 inhibitor compound 48

產(chǎn)品貨號

Axon 2809 CAS [1628210-26-3] MF C17H20N6OMW 324.38 Purity: 99% Soluble in DMSO Description Potent, selective and orally bioavailable KDM5 inhibitor (IC50 value of 15.1 nM for KDM5A) with improved cell potency (EC50 value of 0.34 μM, H3K4Me3 level in PC9 cells). Chemical probe suitable for studying KDM5 biological functions in vivo. KEYWORDS: KDM5 inhibitor compound 48 | supplier | KDM5 inhibitor | CAS [1628210-26-3] | Histone demethylase | Inhibitor | Enzymes | Orally bioavailable | PC9

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

KDM5 inhibitor compound 48

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2809

CAS [1628210-26-3]

MF C17H20N6O
MW 324.38

Purity: 99%
Soluble in DMSO

KDM5 inhibitor compound 48

Description

Potent, selective and orally bioavailable KDM5 inhibitor (IC50 value of 15.1 nM for KDM5A) with improved cell potency (EC50 value of 0.34 μM, H3K4Me3 level in PC9 cells). Chemical probe suitable for studying KDM5 biological functions in vivo.

J Liang et al. Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies. Bioorg Med Chem Lett. 2016 Aug 15;26(16):4036-41.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Epigenetics EC 1.14.11 Histone demethylase

Selective and orally bioavailable KDM5 inhibitor

Chemical name

5-(1-tert-Butyl-1H-pyrazol-4-yl)-6-isopropyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

Parent CAS No.

[1628210-26-3]

產(chǎn)品資料

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