| 產(chǎn)品名稱 | AZD2716 |
| 產(chǎn)品貨號 | Axon 2661 CAS [1845753-81-2] MF C24H23NO3MW 373.44 Purity: 99% Optical purity: 98% e.e. Soluble in 0.1N NaOH (aq) and DMSO Description AZD2716 is a novel, potent sPLA2 inhibitor (IC50 values of 10, 40, and 400 nM for sPLA2-IIa, -V, and -X, respectively) with excellent preclinical pharmacokinetic properties across species, clear in vivo efficacy, and minimized safety risk. When incubated with HepG2 cells, AZD2716 effectively inhibited sPLA2 activity (IC50 value of <14 nM) and suppressed production of sPLA2-IIa (IC50 value of 176 nM). AZD2716 also demonstrated significant sPLA2 activity inhibition (IC50 value of 56 nM) in atherosclerotic plaque homogenates. |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
AZD2716Axon 2661 CAS [1845753-81-2] MF C24H23NO3
DescriptionAZD2716 is a novel, potent sPLA2 inhibitor (IC50 values of 10, 40, and 400 nM for sPLA2-IIa, -V, and -X, respectively) with excellent preclinical pharmacokinetic properties across species, clear in vivo efficacy, and minimized safety risk. When incubated with HepG2 cells, AZD2716 effectively inhibited sPLA2 activity (IC50 value of <14 nM) and suppressed production of sPLA2-IIa (IC50 value of 176 nM). AZD2716 also demonstrated significant sPLA2 activity inhibition (IC50 value of 56 nM) in atherosclerotic plaque homogenates. KEYWORDS: AZD2716 | supplier | sPLA2 inhibitor | AZD 2716 | AZD-2716 | CAS [1845753-81-2] | Phospholipids | PLA2 | Inhibitor | Enzymes | Coronary Artery Disease
Potent secreted phospholipase A2 (sPLA2) inhibitor
Chemical name(R)-3-(5'-Benzyl-2'-carbamoylbiphenyl-3-yl)-2-methylpropanoic acid Parent CAS No.[1845753-81-2] |
| 產(chǎn)品資料 |
