| 產(chǎn)品名稱 | BAY 1895344 |
| 產(chǎn)品貨號(hào) | Axon 2918 CAS [1876467-74-1 ] MF C20H21N7OMW 375.43 Purity: 99% Optical purity: Optically pure Soluble in 0.1N HCl(aq) and DMSO Description BAY 1895344 is a potent, highly selective and orally available ATR inhibitor (IC50 value of 7 nM), which potently inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 value of 78 nM). BAY 1895344 exhibits strong in vivo anti-tumor efficacy in monotherapy in a variety of xenograft models of different indications that are characterized by DDR deficiencies, inducing stable disease in ovarian and colorectal cancer or even complete tumor remission in mantle cell lymphoma models. KEYWORDS: BAY 1895344 | supplier | ATR inhibitor | BAY1895344 | BAY-1895344 | CAS [1876467-74-1] | DNA-damage response | ATR | Inhibitor | Enzymes | Ovarian | Colorectal | Mantle cell lymphoma |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
BAY 1895344Axon 2918 CAS [1876467-74-1 ] MF C20H21N7O
DescriptionBAY 1895344 is a potent, highly selective and orally available ATR inhibitor (IC50 value of 7 nM), which potently inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 value of 78 nM). BAY 1895344 exhibits strong in vivo anti-tumor efficacy in monotherapy in a variety of xenograft models of different indications that are characterized by DDR deficiencies, inducing stable disease in ovarian and colorectal cancer or even complete tumor remission in mantle cell lymphoma models. KEYWORDS: BAY 1895344 | supplier | ATR inhibitor | BAY1895344 | BAY-1895344 | CAS [1876467-74-1] | DNA-damage response | ATR | Inhibitor | Enzymes | Ovarian | Colorectal | Mantle cell lymphoma?
Potent, orally available and highly selective inhibitor of ATR protein kinase
Chemical name(R)-3-Methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine Parent CAS No.[1876467-74-1] |
| 產(chǎn)品資料 |
