| 產(chǎn)品名稱 | CS1 |
| 產(chǎn)品貨號 | Axon 2391 CAS [1448009-94-6] MF C16H12O3MW 252.26 Purity: 99% Soluble in DMSO Description TOPO IIα inhibitor with broad-spectrum in vitro antitumor effects (IC50 values 4.3 μM, 11.5 μM, and 4.6 μM for inhibition of proliferation of breast cancer MDA-MB-231, human lung cancer A549 and human cervical cancer HeLa cell lines, respectively). CS1 functions as a Topo II poison to stabilize Topo II/DNA complex, which leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis, and is 6–10-fold less cytotoxic against HL7702 and HUVEC cells compared with etoposide. References Certificates Categories Extra info W. Chen et al. Design and synthesis of 2-phenylnaphthalenoids as inhibitors of DNA topoisomeraseIIα and antitumor agents. Eur J Med Chem. 2014 Oct 30;86:782-96. ? Y. Shen et al. CS1 is a novel topoisomerase IIα inhibitor with favorable drug resistance profiles. Biochem Biophys Res Commun. 2014 Oct 24;453(3):302-8. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology Immunology DNA-damage Response EC 5.99.1.3 TOPO TOPO IIα inhibitor with broad-spectrum in vitro antitumor effects Chemical name 4-(6-hydroxynaphthalen-2-yl)benzene-1,2-diol Parent CAS No. [1448009-94-6] Order Size Unit Price Stock 10 mg €135.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
CS1Axon 2391 CAS [1448009-94-6] MF C16H12O3
Description
TOPO IIα inhibitor with broad-spectrum in vitro antitumor effects (IC50 values 4.3 μM, 11.5 μM, and 4.6 μM for inhibition of proliferation of breast cancer MDA-MB-231, human lung cancer A549 and human cervical cancer HeLa cell lines, respectively). CS1 functions as a Topo II poison to stabilize Topo II/DNA complex, which leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis, and is 6–10-fold less cytotoxic against HL7702 and HUVEC cells compared with etoposide.
TOPO IIα inhibitor with broad-spectrum in vitro antitumor effects
Chemical name4-(6-hydroxynaphthalen-2-yl)benzene-1,2-diol Parent CAS No.[1448009-94-6] |
| 產(chǎn)品資料 |
