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產(chǎn)品名稱

CHIR 090

產(chǎn)品貨號

Axon 2000 CAS [728865-23-4] MF C24H27N3O5MW 437.49 Purity: 99% Optical purity: Optically pure Soluble in 0.1N HCl(aq) and DMSO Description Very potent and selective UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase LpxC inhibitor (Ki: 1-2 nM and slow, tight-binding) KEYWORDS:?CHIR 090 | supplier | LpxC inhibitor | CHIR090 | CHIR-090 | CAS [728865-23-4] | Lipid A precursor | LpxC | Inhibitor | UDP | glucosamine

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

CHIR 090

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2000

CAS [728865-23-4]

MF C24H27N3O5
MW 437.49

Purity: 99%
Optical purity: Optically pure
Soluble in 0.1N HCl(aq) and DMSO

CHIR 090

Description

Very potent and selective UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase LpxC inhibitor (Ki: 1-2 nM and slow, tight-binding)

KEYWORDS:?CHIR 090 | supplier | LpxC inhibitor | CHIR090 | CHIR-090 | CAS [728865-23-4] | Lipid A precursor | LpxC | Inhibitor | UDP | glucosamine

AL McClerren et al. A Slow, Tight-Binding Inhibitor of the Zinc-Dependent Deacetylase LpxC of Lipid A Biosynthesis with Antibiotic Activity Comparable to Ciprofloxacin. Biochemistry, 2005, 44 (50), 16574–16583.?

?

AW Barb et al. Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding.?PNAS USA?2007, 104 (52), 18433-18438.?

Certificate of Analysis
Material Safety Data Sheet

Immunology LpxC EC 3.5.1.108

Potent and selective LpxC inhibitor

Chemical name

N-((2S,3R)-3-hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide

Parent CAS No.

[728865-23-4]

產(chǎn)品資料

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