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產(chǎn)品名稱

JSH 23

產(chǎn)品貨號(hào)

Axon 2349 CAS [749886-87-1] MF C16H20N2MW 240.34 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Inhibitor of NF-κB transcription and nuclear translocation of p65 (IC50 value 7.1 μM for inhibition of LPS-induced NF-κB transcriptional activity) without affecting IκBα degradation, which is a very rare mode of action. JSH 23 inhibited not only LPS-induced expressions of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and inducible nitric oxide synthase and cyclooxygenase-2 but also LPS-induced apoptosis of the RAW 264.7 cells. JSF 23 also inhibits NO production in LPS-stimulated macrophages RAW 264.7 (IC50 value 14.4 μM). KEYWORDS:?JSH 23 | supplier | NF-κB inhibitor | JSH23 | CAS [749886-87-1] | NF-κB | Inhibitor | p65 | IκB | inflammation | transcription factor | Pro-inflammatory | cytokine | LPS | IKK | RAW 264.7 | COX-2

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

JSH 23

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2349

CAS [749886-87-1]

MF C16H20N2
MW 240.34

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

JSH 23

Description

Inhibitor of NF-κB transcription and nuclear translocation of p65 (IC50 value 7.1 μM for inhibition of LPS-induced NF-κB transcriptional activity) without affecting IκBα degradation, which is a very rare mode of action. JSH 23 inhibited not only LPS-induced expressions of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and inducible nitric oxide synthase and cyclooxygenase-2 but also LPS-induced apoptosis of the RAW 264.7 cells.
JSF 23 also inhibits NO production in LPS-stimulated macrophages RAW 264.7 (IC50 value 14.4 μM).

KEYWORDS:?JSH 23 | supplier | NF-κB inhibitor | JSH23 | CAS [749886-87-1] | NF-κB | Inhibitor | p65 | IκB | inflammation | transcription factor | Pro-inflammatory | cytokine | LPS | IKK | RAW 264.7 | COX-2

K.R. Min et al. Anti-inflammatory effects of N1-benzyl-4-methylbenzene-1,2-diamine (JSH-21) analogs on nitric oxide production and nuclear factor-kappa B transcriptional activity.... Arch. Pharm. Res. 2004, 27, 1053-1059.

H.Y. Fang et al. Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood. 2009, 114, 844-859.

H.M. Shin et al. Inhibitory action of novel aromatic diamine compound on lipopolysaccharide-induced nuclear translocation of NF-kappaB without affecting IkappaB degradation. FEBS Lett. 2004, 571, 50-54.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Signaling & Oncology Pain & Inflammation Transcription Factors NF-κB NF-κB TF class 4.1.1

Inhibitor of NF-κB transcription and nuclear translocation of p65 without affecting IκBα degradation

Chemical name

4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine

Parent CAS No.

[749886-87-1]

產(chǎn)品資料

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