| 產(chǎn)品名稱 | Pregabalin - PD 144723 |
| 產(chǎn)品貨號(hào) | Axon 1823 CAS [148553-50-8] MF C8H17NO2MW 159.23 Purity: 98% Optical purity: Optically pure Soluble in water Description An analogue of γ-amino butyric acid (GABA) but inactive at GABA receptors. Pregabalin binds to the α2δ protein, an auxiliary protein associated with voltage-gated calcium channels in the central nervous system. Pregabalin reduces the synaptic release of several neurotransmitters by binding to α2δ subunits, possibly accounting for its actions in vivo to reduce neuronal excitability and seizures. Antiepileptic and analgesic. References Certificates Categories Extra info CP Taylor et al. Pharmacology and mechanism of action of pregabalin: The calcium channel α2–δ (alpha2–delta) subunit as a target for antiepileptic drug discovery. Epilepsy Res. 2007, 73, 137–150.? ? Y Zhang et al. Development and validation of a direct enantiomeric separation of pregabalin to support isolated perfused rat kidney studies. J. Chrom. B. 2008, 875, 148–153.? Certificate of Analysis Material Safety Data Sheet Cardiovascular Cell Signaling & Oncology CNS Pain & Inflammation α2δ subunit Unclassified Reduces synaptic signaling by binding to α2δ subunits Chemical name (S)-3-(aminomethyl)-5-methylhexanoic acid Parent CAS No. [148553-50-8] Order Size Unit Price Stock 10 mg €85.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
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| 產(chǎn)品詳情 |
Pregabalin - PD 144723Axon 1823 CAS [148553-50-8] MF C8H17NO2
Description
An analogue of γ-amino butyric acid (GABA) but inactive at GABA receptors. Pregabalin binds to the α2δ protein, an auxiliary protein associated with voltage-gated calcium channels in the central nervous system. Pregabalin reduces the synaptic release of several neurotransmitters by binding to α2δ subunits, possibly accounting for its actions in vivo to reduce neuronal excitability and seizures. Antiepileptic and analgesic.
Reduces synaptic signaling by binding to α2δ subunits
Chemical name(S)-3-(aminomethyl)-5-methylhexanoic acid Parent CAS No.[148553-50-8] |
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