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產(chǎn)品名稱

PHA 408

產(chǎn)品貨號(hào)

Axon 1651 CAS [503555-55-3] MF C29H27ClFN7O2MW 560.02 Purity: 99% Soluble in DMSO Description Potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling References Certificates Categories Extra info G Mbalaviele et al. A novel, highly selective, tight binding IkB kinase-2 (IKK-2) inhibitor: a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor-kB pathway (...). J. Ph. Exp. Ther. 2009, 329(1), 14-25. ? CD Sommers et al. Novel tight-binding inhibitory factor-kB kinase (IKK-2) inhibitors demonstrate target-specific anti-inflammatory activities in cellular assays (...). J. Pharmacol. Exp. Ther. 2009, 330(2), 377-388. ? S Rajendrasozhan et al. Anti-inflammatory effect of a selective IkB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke. Pulm. Pharmacol. Ther. 2010, 23(3), 172-181. ? S Mathialagan et al. Expression, purification and functional characterization of IkB kinase-2 (IKK-2) mutants. Protein Expr. Purif. 2010, 72(2), 254-261. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Immunology Pain & Inflammation Transcription Factors NF-κB EC 2.7.11.10 IKK IKK-2 inhibitor Chemical name 8-(5-chloro-2-(4-methylpiperazin-1-yl)isonicotinamido)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide Parent CAS No. [503555-55-3] Order Size Unit Price Stock 5 mg €105.00 In Stock

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

PHA 408

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 1651

CAS [503555-55-3]

MF C29H27ClFN7O2
MW 560.02

Purity: 99%
Soluble in DMSO

PHA 408

Description

Potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling

G Mbalaviele et al. A novel, highly selective, tight binding IkB kinase-2 (IKK-2) inhibitor: a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor-kB pathway (...). J. Ph. Exp. Ther. 2009, 329(1), 14-25.

CD Sommers et al. Novel tight-binding inhibitory factor-kB kinase (IKK-2) inhibitors demonstrate target-specific anti-inflammatory activities in cellular assays (...). J. Pharmacol. Exp. Ther. 2009, 330(2), 377-388.

S Rajendrasozhan et al. Anti-inflammatory effect of a selective IkB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke. Pulm. Pharmacol. Ther. 2010, 23(3), 172-181.

S Mathialagan et al. Expression, purification and functional characterization of IkB kinase-2 (IKK-2) mutants. Protein Expr. Purif. 2010, 72(2), 254-261.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Immunology Pain & Inflammation Transcription Factors NF-κB EC 2.7.11.10 IKK

IKK-2 inhibitor

Chemical name

8-(5-chloro-2-(4-methylpiperazin-1-yl)isonicotinamido)-1-(4-fluorophenyl)-4,5-dihydro-1H-benzo[g]indazole-3-carboxamide

Parent CAS No.

[503555-55-3]

產(chǎn)品資料

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