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產(chǎn)品名稱

LXR 623 - WAY 252623

產(chǎn)品貨號

Axon 2357 CAS [875787-07-8] MF C21H12ClF5N2MW 422.78 Purity: 99% Soluble in DMSO Description Partial agonist of Liver X Receptor (LXR; IC50 value 179 nM and 24 nM for LXRα- and LXRβ-binding, respectively. EC50 values 6.66 μM and 3.67 μM for Huh-7 human hepatoma cell based Gal4 LXRα and LXRβ transactivation essays respectively). Despite its partial agonism in transactivation essays, LXR 623 exhibits full agonism in THP-1 cells with respect to increasing ABCA1 gene expression and on cholesterol efflux in THP-1 foam cells. In vivo, LXR 623 lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. References Certificates Categories Extra info C. Giannarelli et al. Synergistic effect of liver X receptor activation and simvastatin on plaque regression and stabilization: an magnetic resonance imaging study in a model of advanced atherosclerosis. Eur. Heart J. 2012, 33, 264-273. ? J. Wrobel et al. Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis. J. Med. Chem. 2008, 51, 7161-7168. ? E.M. Quinet et al. LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J. Lipid Res. 2009, 50, 2358-2370. ? E.A. DiBlasio-Smith et al. Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. J. Transl. Med. 2008, 6, 59. Certificate of Analysis Material Safety Data Sheet Cardiovascular Diabetes & Metabolism NR1H LXR Partial agonist of Liver X Receptor Chemical name 2-(2-chloro-4-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole Parent CAS No. [875787-07-8] Order Size Unit Price Stock 10 mg €95.00 In Stock

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現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

LXR 623 - WAY 252623

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2357

CAS [875787-07-8]

MF C21H12ClF5N2
MW 422.78

Purity: 99%
Soluble in DMSO

LXR 623

Description

Partial agonist of Liver X Receptor (LXR; IC50 value 179 nM and 24 nM for LXRα- and LXRβ-binding, respectively. EC50 values 6.66 μM and 3.67 μM for Huh-7 human hepatoma cell based Gal4 LXRα and LXRβ transactivation essays respectively). Despite its partial agonism in transactivation essays, LXR 623 exhibits full agonism in THP-1 cells with respect to increasing ABCA1 gene expression and on cholesterol efflux in THP-1 foam cells. In vivo, LXR 623 lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse.

C. Giannarelli et al. Synergistic effect of liver X receptor activation and simvastatin on plaque regression and stabilization: an magnetic resonance imaging study in a model of advanced atherosclerosis. Eur. Heart J. 2012, 33, 264-273.

J. Wrobel et al. Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis. J. Med. Chem. 2008, 51, 7161-7168.

E.M. Quinet et al. LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J. Lipid Res. 2009, 50, 2358-2370.

E.A. DiBlasio-Smith et al. Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. J. Transl. Med. 2008, 6, 59.

Certificate of Analysis
Material Safety Data Sheet

Cardiovascular Diabetes & Metabolism NR1H LXR

Partial agonist of Liver X Receptor

Chemical name

2-(2-chloro-4-fluorobenzyl)-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole

Parent CAS No.

[875787-07-8]

產(chǎn)品資料

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