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產(chǎn)品名稱(chēng)

BX 795

產(chǎn)品貨號(hào)

Axon 1390 CAS [702675-74-9] MF C23H26IN7O2SMW 591.47 Purity: 98% Soluble in DMSO Description BX 795 was initially developed as a PDPK1 inhibitor. Recent study highlighted on its bioactivitiy as a potent and relatively specific inhibitor of TBK1 and closely related IKKε, with IC50 values to be 6, 41, and 111 nM for TBK1, IKKε and PDPK1 respectively. KEYWORDS:?BX 795 | supplier | PDK1/TBK1 inhibitor | BX795 | BX-795 | CAS [702675-74-9] | Phosphatidylinositol | IKK | PDPK | PDK1 | TBK | TBK1 | IKK-epsilon

產(chǎn)品價(jià)格

現(xiàn)貨詢(xún)價(jià)，電話(huà)：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

BX 795

Based on 406 reference(s) in Google Scholar 8 10 406

Axon 1390

CAS [702675-74-9]

MF C23H26IN7O2S
MW 591.47

Purity: 98%
Soluble in DMSO

BX 795

Description

BX 795 was initially developed as a PDPK1 inhibitor. Recent study highlighted on its bioactivitiy as a potent and relatively specific inhibitor of TBK1 and closely related IKKε, with IC50 values to be 6, 41, and 111 nM for TBK1, IKKε and PDPK1 respectively.

KEYWORDS:?BX 795 | supplier | PDK1/TBK1 inhibitor | BX795 | BX-795 | CAS [702675-74-9] | Phosphatidylinositol | IKK | PDPK | PDK1 | TBK | TBK1 | IKK-epsilon

R I Feldman et al. Novel Small Molecule Inhibitors of 3-Phosphoinositide-dependent Kinase-1. J. Biol. Chem., 2005, 280, 20, 19867-19874.

J Bain et al. The selectivity of protein kinase inhibitors: a further update. Biochem. J. 2007, 408, 297–315.

C Peifer, D?R. Alessi, Small-Molecule Inhibitors of PDK1. ChemMedChem. 2008, 3 (12), 1810–1838.

K Clark et al. Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IκB kinase ?: a distinct upstream kinase mediates SER-172 phosphoylation and activation. J. Biol. Chem. 2009, 284, 14136-14146.

List of publications using BX 795 (Axon 1390) purchased from Axon Medchem

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Immunology Pain & Inflammation Transcription Factors NF-κB PI3K-Akt-mTOR EC 2.7.11.1 PDPK IKK TBK

PDPK1, TBK1 and IKK inhibitor

Chemical name

Pyrrolidine-1-carboxylic acid [3-(5-iodo-4-{3-[(thiophene-2-carbonyl)-amino]-propylamino}-pyrimidin-2-ylamino)-phenyl]-amide

Parent CAS No.

[702675-74-9]

產(chǎn)品資料

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