| 產(chǎn)品名稱 | Crizotinib, (S)- |
| 產(chǎn)品貨號 | Axon 2296 CAS [1374356-45-2] MF C21H22Cl2FN5OMW 450.34 Purity: 99% Optical purity: 98.5 % e.e. Soluble in DMSO Description (S)-Crizotinib is a selective inhibitor of the human mutT homologue MTH1 (also known as NUDT1; IC50 value 72 nM; Kd value 48 nM). MTH1 inhibition by (S)-Crizotinib induced an increase in DNA single-strand breaks, activated DNA repair in human colon carcinoma cells, and effectively suppressed tumor growth in animal models. It is the opposite (S)-enantiomer of (R)-Crizotinib (PF-02341066, Axon 1660), which is a ALK/MET inhibitor. MTH1 (human mutT homologue, or NUDT1) has been implicated in aiding RAS-transformed cells to overcome oncogene-induced senescence by preventing reactive oxygen species (ROS)-induced DNA damage. References Certificates Categories Extra info K.V.M. Huber et al. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature. 2014, 508, 222-227. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology DNA-damage Response MTH1 EC 3.6.1.56 MTH1 inhibitor Chemical name (S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine Parent CAS No. [1374356-45-2] Order Size Unit Price Stock 5 mg €85.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
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Crizotinib, (S)-Axon 2296 CAS [1374356-45-2] MF C21H22Cl2FN5O
Description(S)-Crizotinib is a selective inhibitor of the human mutT homologue MTH1 (also known as NUDT1; IC50 value 72 nM; Kd value 48 nM). MTH1 inhibition by (S)-Crizotinib induced an increase in DNA single-strand breaks, activated DNA repair in human colon carcinoma cells, and effectively suppressed tumor growth in animal models.
MTH1 inhibitor
Chemical name(S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine Parent CAS No.[1374356-45-2] |
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