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產(chǎn)品名稱

PX 20350 - FXR agonist Cpd 22

產(chǎn)品貨號

Axon 2152 CAS [1198085-23-2] MF C28H22Cl2F3N3O4MW 592.39 Purity: 99% Soluble in DMSO Description Potent farnesoid X receptor (FXR) agonist with enhanced affinity and efficacy (12 nM and 109% (compared to GW 4064)) in FXR FRET assay and full length FXR direct reporter (DR) assay (6 nM vs 30 nM for GW 4064). Cpd 22 showed a linear dose-dependent reduction in total plasma triglycerides and total plasma cholesterol. References Certificates Categories Extra info U. Abel et al. Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists. Bioorg. Med. Chem. Lett. 2010, 20, 4911–4917.? ? U. Deuschle et al. FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model. PLoS One. 2012, 7, e43044.? Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology FXR NR1H Potent farnesoid X receptor (FXR) agonist Chemical name 4-(((6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-(trifluoromethyl)pyridin-3-yl)(methyl)amino)methyl)benzoic acid Parent CAS No. [1198085-23-2] Order Size Unit Price Stock 5 mg €105.00 In Stock

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

PX 20350 - FXR agonist Cpd 22

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2152

CAS [1198085-23-2]

MF C28H22Cl2F3N3O4
MW 592.39

Purity: 99%
Soluble in DMSO

PX 20350

Description

Potent farnesoid X receptor (FXR) agonist with enhanced affinity and efficacy (12 nM and 109% (compared to GW 4064)) in FXR FRET assay and full length FXR direct reporter (DR) assay (6 nM vs 30 nM for GW 4064). Cpd 22 showed a linear dose-dependent reduction in total plasma triglycerides and total plasma cholesterol.

U. Abel et al. Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists. Bioorg. Med. Chem. Lett. 2010, 20, 4911–4917.?

U. Deuschle et al. FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model. PLoS One. 2012, 7, e43044.?

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology FXR NR1H

Potent farnesoid X receptor (FXR) agonist

Chemical name

4-(((6-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-2-(trifluoromethyl)pyridin-3-yl)(methyl)amino)methyl)benzoic acid

Parent CAS No.

[1198085-23-2]

產(chǎn)品資料

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