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產(chǎn)品名稱

Alpelisib - NVP-BYL719 | BYL-719

產(chǎn)品貨號

Axon 2925 CAS [1217486-61-7] MF C19H22F3N5O2SMW 441.47 Purity: 98% Optical purity: Optically pure Soluble in DMSO Description Alpelisib is a potent and selective PI3K α-isoform inhibitor with an IC50 value of 5 nM. Moreover, Alpelisib has shown good efficacy in inhibiting the growth of PI3K α-isoform driven tumors in animal xenograft models as well as good tolerability. KEYWORDS: Alpelisib | supplier | PI3K inhibitor | NVP-BYL719 | BYL-719 | NVPBYL719 | BYL719 | BYL 719 | CAS [1217486-61-7] | CAS [1584128-91-5] | Phosphatidylinositol | PI3K | Inhibitor | Enzymes

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Alpelisib - NVP-BYL719 | BYL-719

Based on 102 reference(s) in Google Scholar 8 10 102

Axon 2925

CAS [1217486-61-7]

MF C19H22F3N5O2S
MW 441.47

Purity: 98%
Optical purity: Optically pure
Soluble in DMSO

Alpelisib

Description

Alpelisib is a potent and selective PI3K α-isoform inhibitor with an IC50 value of 5 nM. Moreover, Alpelisib has shown good efficacy in inhibiting the growth of PI3K α-isoform driven tumors in animal xenograft models as well as good tolerability.

KEYWORDS: Alpelisib | supplier | PI3K inhibitor | NVP-BYL719 | BYL-719 | NVPBYL719 | BYL719 | BYL 719 | CAS [1217486-61-7] | CAS [1584128-91-5] | Phosphatidylinositol | PI3K | Inhibitor | Enzymes

P Furet et al. Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3741-8.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology PI3K PI3K-Akt-mTOR EC 2.7.1.153

PI3K inhibitor (p110-α specific)

Chemical name

(S)-N1-(4-Methyl-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-yl)pyrrolidine-1,2-dicarboxamide

Parent CAS No.

[1217486-61-7]

產(chǎn)品資料

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