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產(chǎn)品名稱

SC 236 - SC 58236

產(chǎn)品貨號

Axon 2108 CAS [170569-86-5] MF C16H11ClF3N3O2SMW 401.79 Purity: 99% Soluble in DMSO Description Selective COX-2 inhibitor, which showed an impressive selectivity for COX-2 over COX-1 (IC50 0.01 μM vs. 17.8 μM respectively); NSAID and early lead compound during the discovery of Celecoxib (Axon 1919). However, SC236 showed an extremely long plasma half-life, not preferred for further development as potential therapeutic References Certificates Categories Extra info TD Penning et al. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene (...). J. Med. Chem. 1997, 40(9), 1347-1365.? ? A Planagumà et al. The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARγ activation. FASEB J. 2005, 19(9), 1120-1122.? Certificate of Analysis Material Safety Data Sheet CNS Immunology Pain & Inflammation EC 1.14.99.1 COX Pfizer Licensed Products Selective COX-2 inhibitor Chemical name 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide Source information Pfizer compound; Sold for research purposes under agreement from Pfizer Inc. Parent CAS No. [170569-86-5] Order Size Unit Price Stock 10 mg €80.00 In Stock

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

SC 236 - SC 58236

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2108

CAS [170569-86-5]

MF C16H11ClF3N3O2S
MW 401.79

Purity: 99%
Soluble in DMSO

SC 236

Description

Selective COX-2 inhibitor, which showed an impressive selectivity for COX-2 over COX-1 (IC50 0.01 μM vs. 17.8 μM respectively); NSAID and early lead compound during the discovery of Celecoxib (Axon 1919). However, SC236 showed an extremely long plasma half-life, not preferred for further development as potential therapeutic

TD Penning et al. Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene (...). J. Med. Chem. 1997, 40(9), 1347-1365.?

A Planagumà et al. The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARγ activation. FASEB J. 2005, 19(9), 1120-1122.?

Certificate of Analysis
Material Safety Data Sheet

CNS Immunology Pain & Inflammation EC 1.14.99.1 COX Pfizer Licensed Products

Selective COX-2 inhibitor

Chemical name

4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide

Source information

Pfizer compound; Sold for research purposes under agreement from Pfizer Inc.

Parent CAS No.

[170569-86-5]

產(chǎn)品資料

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