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產(chǎn)品名稱

RO 4929097

產(chǎn)品貨號

Axon 2521 CAS [847925-91-1] MF C22H20F5N3O3MW 469.40 Purity: 98% Optical purity: Optically pure Soluble in DMSO Description Potent γ-secretase inhibitor (GSI; IC50 value 4 nM) targeting Notch signaling with in vivo efficacy in various tumor cells, showing >100-fold selectivity with respect to 75 other proteins of various types (receptors, ion channels, and enzymes). Treatment of HEK293 cells with RO4929097 caused a dose-dependent decrease in the amount of Aβ peptides secreted into the culture medium (EC50 value 14 nM), and a strong dose-dependent inhibition of Notch processing in a Notch cell-based reporter assay (EC50 value 5 nM). KEYWORDS: RO 4929097 | Supplier | γ-Secretase inhibitor | RO4929097 | CAS [847925-91-1] | Amyloids | γ Secretase | Inhibitor | GSI | Notch | signaling | Aβ peptides | tumor | melanoma | gamma Secretase

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

RO 4929097

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2521

CAS [847925-91-1]

MF C22H20F5N3O3
MW 469.40

Purity: 98%
Optical purity: Optically pure
Soluble in DMSO

RO 4929097

Description

Potent γ-secretase inhibitor (GSI; IC50 value 4 nM) targeting Notch signaling with in vivo efficacy in various tumor cells, showing >100-fold selectivity with respect to 75 other proteins of various types (receptors, ion channels, and enzymes). Treatment of HEK293 cells with RO4929097 caused a dose-dependent decrease in the amount of Aβ peptides secreted into the culture medium (EC50 value 14 nM), and a strong dose-dependent inhibition of Notch processing in a Notch cell-based reporter assay (EC50 value 5 nM).

C. Huynh et al. The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma. PLoS One. 2011;6(9):e25264.

L. Luistro et al. Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties. Cancer Res. 2009 Oct 1;69(19):7672-80.

M.M. Gounder et al. Moving forward one Notch at a time. J Clin Oncol. 2012 Jul 1;30(19):2291-3.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology CNS Stem Cell γ Secretase EC 3.4.23.46

Potent γ-secretase inhibitor (GSI) targeting Notch signaling in various tumor cells

Chemical name

(S)-2,2-dimethyl-N1-(6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N3-(2,2,3,3,3-pentafluoropropyl)malonamide

Parent CAS No.

[847925-91-1]

產(chǎn)品資料

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