| 產(chǎn)品名稱 | Isoquinolinediol, 1,5- - NSC 65585 |
| 產(chǎn)品貨號(hào) | Axon 2537 CAS [5154-02-9] MF C9H7NO2MW 161.16 Purity: 100% Soluble in 0.1N NaOH(aq) and DMSO Description PARP1-specific inhibitor (IC50 value 0.39 - 1.00 μM) and neuroprotective agent, that leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene in mouse Ltk cells. Treatment of 1,5-Isoquinolinediol significantly blocked mitochondrial membrane potential loss and AIF (apoptosis inducing factor) and cytochrome c release from the mitochondria. 1,5-Isoquinolinediol did not suppress pristimerin-induced JNK activation. KEYWORDS: 1,5-Isoquinolinediol | supplier | PARP inhibitor |NSC65585 |NSC65585 | CAS [5154-02-9] |DNA-RNA | PARP1 | Inhibitor | DHIQ | DIQ | poly |ADP-ribose | SSB | single strand breaks | Ltk cells | mitochondrial membrane potential |AIF| apoptosis inducing factor | neuroprotetcive | JNK |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
Isoquinolinediol, 1,5- - NSC 65585Axon 2537 CAS [5154-02-9] MF C9H7NO2
DescriptionPARP1-specific inhibitor (IC50 value 0.39 - 1.00 μM) and neuroprotective agent, that leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene in mouse Ltk cells. Treatment of 1,5-Isoquinolinediol significantly blocked mitochondrial membrane potential loss and AIF (apoptosis inducing factor) and cytochrome c release from the mitochondria. 1,5-Isoquinolinediol did not suppress pristimerin-induced JNK activation. KEYWORDS: 1,5-Isoquinolinediol | supplier | PARP inhibitor |NSC65585 |NSC65585 | CAS [5154-02-9] |DNA-RNA | PARP1 | Inhibitor | DHIQ | DIQ | poly |ADP-ribose | SSB | single strand breaks | Ltk cells | mitochondrial membrane potential |AIF| apoptosis inducing factor | neuroprotetcive | JNK
PARP1 inhibitor and neuroprotective agent
Chemical name5-hydroxyisoquinolin-1(2H)-one Parent CAS No.[5154-02-9] |
| 產(chǎn)品資料 |
