| 產(chǎn)品名稱 | SMI 481 - 6748-481 |
| 產(chǎn)品貨號(hào) | Axon 2387 CAS [432020-20-7] MF C17H15ClFN3O3MW 363.77 Purity: 99% Soluble in DMSO Description Small-molecule inhibitor (SMI) of the yeast PITP Sec14 (IC50 values of 211 nM and 2.87 μM for Sec14 mediated [3H]PtdIns transfer in vitro, and Sec14 dependent cell growth inhibition of WT (CTY182, gray) strains, respectively). SMI481 (aka 6748-481 ) is a water-soluble bioactive compound exhibiting exquisite pathway selectivity in inhibiting phosphoinositide signaling in cells with >200-fold selectivity over other yeast Sec14-like transfer activities. PITP-?directed SMIs offer new and generally applicable avenues for intervening with phosphoinositide signaling pathways with selectivities superior to those afforded by contemporary lipid kinase-?directed strategies. References Certificates Categories Extra info A.H. Nile et al. PITPs as targets for selectively interfering with phosphoinositide signaling in cells. Nat Chem Biol. 2014 Jan;10(1):76-84. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS Sec14 First small-molecule inhibitor (SMI) of the yeast PITP Sec14 Chemical name (4-chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)methanone Parent CAS No. [432020-20-7] Order Size Unit Price Stock 10 mg €80.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
SMI 481 - 6748-481Axon 2387 CAS [432020-20-7] MF C17H15ClFN3O3
Description
Small-molecule inhibitor (SMI) of the yeast PITP Sec14 (IC50 values of 211 nM and 2.87 μM for Sec14 mediated [3H]PtdIns transfer in vitro, and Sec14 dependent cell growth inhibition of WT (CTY182, gray) strains, respectively). SMI481 (aka 6748-481 ) is a water-soluble bioactive compound exhibiting exquisite pathway selectivity in inhibiting phosphoinositide signaling in cells with >200-fold selectivity over other yeast Sec14-like transfer activities. PITP-?directed SMIs offer new and generally applicable avenues for intervening with phosphoinositide signaling pathways with selectivities superior to those afforded by contemporary lipid kinase-?directed strategies.
First small-molecule inhibitor (SMI) of the yeast PITP Sec14
Chemical name(4-chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)methanone Parent CAS No.[432020-20-7] |
| 產(chǎn)品資料 |
