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產(chǎn)品名稱

UPF 1069

產(chǎn)品貨號(hào)

Axon 2369 CAS [1048371-03-4] MF C17H13NO3MW 279.29 Purity: 99% Soluble in DMSO Description PARP-2 inhibitor with >26 fold selectivity over PARP1 (IC50 values 8.0 μM and 0.3 μM for PARP1 and PARP2, respectively) that exacerbates oxygen-glucose deprivation (OGD) injury in the hippocampus, but significantly attenuates OGD damage in mixed cortical cell cultures at concentrations high enough to inhibit both PARP1 and PARP2. UPF 1069 is a valuable tool to explore the function of PARP-2 in biological systems and to examine the different roles of PARP isoenzymes in the mechanisms of cell death and survival. References Certificates Categories Extra info F. Moroni et al. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br. J. Pharmacol. 2009, 157, 854-862. ? R. Pellicciari et al. On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. ChemMedChem. 2008, 3, 914-923. ? T. Haikarainen et al. Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors. ACS Med. Chem. Lett. 2013, 5, 18-22. Certificate of Analysis Material Safety Data Sheet Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology CNS Epigenetics DNA-damage Response EC 2.4.2.30 PARP PARP-2 inhibitor with >26 fold selectivity over PARP1 Chemical name 5-(2-oxo-2-phenylethoxy)isoquinolin-1(2H)-one Parent CAS No. [1048371-03-4] Order Size Unit Price Stock 10 mg €75.00 In Stock

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

UPF 1069

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2369

CAS [1048371-03-4]

MF C17H13NO3
MW 279.29

Purity: 99%
Soluble in DMSO

UPF 1069

Description

PARP-2 inhibitor with >26 fold selectivity over PARP1 (IC50 values 8.0 μM and 0.3 μM for PARP1 and PARP2, respectively) that exacerbates oxygen-glucose deprivation (OGD) injury in the hippocampus, but significantly attenuates OGD damage in mixed cortical cell cultures at concentrations high enough to inhibit both PARP1 and PARP2. UPF 1069 is a valuable tool to explore the function of PARP-2 in biological systems and to examine the different roles of PARP isoenzymes in the mechanisms of cell death and survival.

F. Moroni et al. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br. J. Pharmacol. 2009, 157, 854-862.

R. Pellicciari et al. On the way to selective PARP-2 inhibitors. Design, synthesis, and preliminary evaluation of a series of isoquinolinone derivatives. ChemMedChem. 2008, 3, 914-923.

T. Haikarainen et al. Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors. ACS Med. Chem. Lett. 2013, 5, 18-22.

Certificate of Analysis
Material Safety Data Sheet

Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology CNS Epigenetics DNA-damage Response EC 2.4.2.30 PARP

PARP-2 inhibitor with >26 fold selectivity over PARP1

Chemical name

5-(2-oxo-2-phenylethoxy)isoquinolin-1(2H)-one

Parent CAS No.

[1048371-03-4]

產(chǎn)品資料

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