| 產(chǎn)品名稱(chēng) | SHP099 |
| 產(chǎn)品貨號(hào) | Axon 2633 CAS [1801747-42-1] MF C16H19Cl2N5MW 352.26 Purity: 99% Soluble in DMSO Description Highly potent, selective and orally bioavailable SHP2 inhibitor (IC50 value 0.071 μM) that stabilizes SHP2 in an auto-inhibited conformation. SHP099 potently inhibits ERK phosphorylation and the growth of cancer cell lines that have alterations in RTKs or other tyrosine kinases such as the Janus kinases JAK1 and JAK2. SHP099 showed no detectable activity against a panel of 21 phosphatases and 66 kinases (including the closest homologue SHP1), and only had modest activity against 5HT3 when profiled against a preclinical safety pharmacology panel representing 49 common adverse drug reaction targets. KEYWORDS:?SHP099 | supplier | SHP2 inhibitor | SHP-099 | SHP 099 | CAS [1801747-42-1] | [1801747-11-4] | Tyrosine Phosphatase | PTP | PTPN11 | PTP-2C | programmed cell death pathway | PD-1/PD-L1 | Noonan | Leopard | RAS-ERK signaling |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢(xún)價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
SHP099Axon 2633 CAS [1801747-42-1] MF C16H19Cl2N5
DescriptionHighly potent, selective and orally bioavailable SHP2 inhibitor (IC50 value 0.071 μM) that stabilizes SHP2 in an auto-inhibited conformation. SHP099 potently inhibits ERK phosphorylation and the growth of cancer cell lines that have alterations in RTKs or other tyrosine kinases such as the Janus kinases JAK1 and JAK2. SHP099 showed no detectable activity against a panel of 21 phosphatases and 66 kinases (including the closest homologue SHP1), and only had modest activity against 5HT3 when profiled against a preclinical safety pharmacology panel representing 49 common adverse drug reaction targets. KEYWORDS:?SHP099 | supplier | SHP2 inhibitor | SHP-099 | SHP 099 | CAS [1801747-42-1] | [1801747-11-4] | Tyrosine Phosphatase | PTP | PTPN11 | PTP-2C | programmed cell death pathway | PD-1/PD-L1 | Noonan | Leopard | RAS-ERK signaling
Highly potent, selective and orally bioavailable SHP2 inhibitor
Chemical name6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine Parent CAS No.[1801747-42-1] |
| 產(chǎn)品資料 |
