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產(chǎn)品名稱

Mitapivat

產(chǎn)品貨號

Axon 2149 CAS [1260075-17-9] MF C24H26N4O3SMW 450.55 Purity: 99% Soluble in DMSO Description Activator of pyruvate kinase isoenzyme M2 (PKM2), an enzyme involved in glycolysis. Since all tumor cells exclusively express the embryonic M2 isoform of PK, it is hypothesized that PKM2 is a potential target for cancer therapy. Modulation of PKM2 might also be effective in the treatment of obesity, diabetes, autoimmune conditions, and antiproliferation-dependent diseases. KEYWORDS: Mitapivat | supplier | PKM2 activator | CAS [1260075-17-9] | Pyruvate | PKM2 | Isoenzyme M2 | Iso-enzyme | Activator | Enzymes

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Mitapivat

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2149

CAS [1260075-17-9]

MF C24H26N4O3S
MW 450.55

Purity: 99%
Soluble in DMSO

Mitapivat

Description

Activator of pyruvate kinase isoenzyme M2 (PKM2), an enzyme involved in glycolysis. Since all tumor cells exclusively express the embryonic M2 isoform of PK, it is hypothesized that PKM2 is a potential target for cancer therapy. Modulation of PKM2 might also be effective in the treatment of obesity, diabetes, autoimmune conditions, and antiproliferation-dependent diseases.

C Kung. Activators of pyruvate kinase M2 and methods of treating disease. PCT Int. Appl. WO 2013056153 A1.?

FG Salituro et al. Preparation of aroylpiperazines and related compounds as pyruvate kinase M2 modulators useful in treatment of cancer. U.S. Pat. Appl. US 20100331307 A1.?

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Diabetes & Metabolism Immunology PKM2 EC 2.7.1.40

Activator of pyruvate kinase isoenzyme M2 (PKM2)

Chemical name

N-(4-(4-(cyclopropylmethyl)piperazine-1-carbonyl)phenyl)quinoline-8-sulfonamide

Parent CAS No.

[1260075-17-9]

產(chǎn)品資料

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