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產(chǎn)品名稱

AGI 5198 - IDH-C35

產(chǎn)品貨號(hào)

Axon 2122 CAS [1355326-35-0] MF C27H31FN4O2MW 462.56 Purity: 100% Soluble in DMSO Description Potent inhibitor of mutant isocitrate dehydrogenase 1 (IDH1); selective for IDH1 R132H and R132C mutants in vitro with IC50 values of 0.07 and 0.16 μM, respectively; it delays growth and promotes differentiation of glioma cells. KEYWORDS: AGI 5198 | supplier | IDH1 inhibitor | IDH-C35 | CAS [1355326-35-0] | Isocitrate | IDH | Inhibitor | Enzymes

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

AGI 5198 - IDH-C35

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2122

CAS [1355326-35-0]

MF C27H31FN4O2
MW 462.56

Purity: 100%
Soluble in DMSO

AGI 5198

Description

Potent inhibitor of mutant isocitrate dehydrogenase 1 (IDH1); selective for IDH1 R132H and R132C mutants in vitro with IC50 values of 0.07 and 0.16 μM, respectively; it delays growth and promotes differentiation of glioma cells.

D Rohle et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science, 2013, 340(6132), 626-630.?

FE Garrett-Bakelman and AM Melnick. Differentiation therapy for IDH1/2 mutant malignancies. Cell Res. 2013, 23, 975–977.??

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Diabetes & Metabolism EC 1.1.1.42 Stem Cell Differentiator IDH

Inhibitor of R132 mutant isocitrate dehydrogenase 1 (IDH1)

Chemical name

N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-methyl-1H-imidazol-1-yl)acetamido)-2-o-tolylacetamide

Parent CAS No.

[1355326-35-0]

產(chǎn)品資料

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