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產品名稱

6,8-Bis(benzylthio)octanoic acid

產品貨號

Axon 2125 CAS [95809-78-2] MF C22H28O2S2MW 388.59 Purity: 100% Soluble in 0.1N NaOH(aq) and DMSO Description A small molecular inhibitor of a mitochondrial enzyme pyruvate dehydrogenase (PDH) complex; 6,8-bis(benzylthio)octanoic acid selectively attacks the regulatory aspects of tumor cell mitochondrial metabolism, activating both apoptotic (programmed cell death) and non-apoptotic (necrosis-like) cell death pathways. KEYWORDS: 6,8-Bis(benzylthio)octanoic acid | PDH inhibitor | CAS [95809-78-2] | Pyruvate | PDH | Inhibitor | Enzymes

產品價格

現貨詢價，電話：010-67529703

產品規(guī)格

產品品牌

axonmedchem

產品概述

產品詳情

6,8-Bis(benzylthio)octanoic acid

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2125

CAS [95809-78-2]

MF C22H28O2S2
MW 388.59

Purity: 100%
Soluble in 0.1N NaOH(aq) and DMSO

6,8-Bis(benzylthio)octanoic acid

Description

A small molecular inhibitor of a mitochondrial enzyme pyruvate dehydrogenase (PDH) complex; 6,8-bis(benzylthio)octanoic acid selectively attacks the regulatory aspects of tumor cell mitochondrial metabolism, activating both apoptotic (programmed cell death) and non-apoptotic (necrosis-like) cell death pathways.

Z Zachar et al. Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J. Mol. Med. (Berl). 2011, 89(11), 1137-1148.?

KC Lee et al. Formation and anti-tumor activity of uncommon in vitro and in vivo metabolites of CPI-613, a novel anti-tumor compound that selectively alters tumor energy metabolism. Drug Metab. Lett. 2011, 5(3), 163-182.?

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Diabetes & Metabolism PDH EC 1.2.4.1

Inhibitor of mitochondrial pyruvate dehydrogenase (PDH) complex

Chemical name

6,8-Bis(benzylthio)octanoic acid

Parent CAS No.

[95809-78-2]

產品資料

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