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產(chǎn)品名稱

ASP 9521

產(chǎn)品貨號

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

ASP 9521

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2787

CAS [1126084-37-4]

MF C19H26N2O3
MW 330.42

Purity: 99%
Soluble in DMSO

ASP 9521

Description

ASP 9521 is a novel, selective, orally bioavailable inhibitor of 17β–hydroxysteroid dehydrogenase type 5 (17β-HSD5; AKR1C3) with IC50 values of 11 and 49 nM in recombinant human and cynomolgus monkey AKR1C3, respectively.

A Kikuchi et al. In vitro and in vivo characterisation of ASP9521: a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). Invest New Drugs. 2014 Oct;32(5):860-70.

Y Loriot et al. Safety, tolerability and anti-tumour activity of the androgen biosynthesis inhibitor ASP9521 in patients with metastatic castration-resistant prostate cancer: multi-centre phase I/II study. Invest New Drugs. 2014 Oct;32(5):995-1004.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Endocrinology Dehydrogenase (17β-hydroxysteroid, type 5) EC 1.1.1.51

Inhibitor of 17 β–hydroxysteroid dehydrogenase type 5

Chemical name

(4-(2-Hydroxy-2-methylpropyl)piperidin-1-yl)(5-methoxy-1H-indol-2-yl)methanone

Parent CAS No.

[1126084-37-4]

產(chǎn)品資料

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