| 產(chǎn)品名稱 | Alda 1 |
| 產(chǎn)品貨號 | Axon 2551 CAS [349438-38-6] MF C15H11Cl2NO3MW 324.16 Purity: 99% Soluble in DMSO Description Small molecule activator of ALDH2 (EC50 value ca 6 μM for ALDH2 mediated acetaldehyde metabolism) with the ability to activate wild-type ALDH2 and restore near-wild-type activity to ALDH2*2. When administered to rats before an ischemic event, Alda 1 reduced infarct size by 60%, most likely through its inhibitory effect on the formation of cytotoxic aldehydes. Alda-1 was effective in protecting against rotenone-induced apoptotic cell death in both SH-SY5Y cells and primary cultured substantia nigra (SN) dopaminergic neurons, and significantly reduced rotenone- or MPTP-induced death of SN tyrosine hydroxylase (TH)-positive dopaminergic neurons. KEYWORDS: Alda 1 | supplier | ALDH2 activator | Alda1 | CAS [349438-38-6] | Alcohol | ALDH | Activator | agonist | ALDH2*2 | dehydrogenase | alcoholism | ischemia | chaperone | neuroprotective | dopamine neurons | rotenone | MPTP | substantia nigra |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
Alda 1Axon 2551 CAS [349438-38-6] MF C15H11Cl2NO3
DescriptionSmall molecule activator of ALDH2 (EC50 value ca 6 μM for ALDH2 mediated acetaldehyde metabolism) with the ability to activate wild-type ALDH2 and restore near-wild-type activity to ALDH2*2. When administered to rats before an ischemic event, Alda 1 reduced infarct size by 60%, most likely through its inhibitory effect on the formation of cytotoxic aldehydes. Alda-1 was effective in protecting against rotenone-induced apoptotic cell death in both SH-SY5Y cells and primary cultured substantia nigra (SN) dopaminergic neurons, and significantly reduced rotenone- or MPTP-induced death of SN tyrosine hydroxylase (TH)-positive dopaminergic neurons. KEYWORDS: Alda 1 | supplier | ALDH2 activator | Alda1 | CAS [349438-38-6] | Alcohol | ALDH | Activator | agonist | ALDH2*2 | dehydrogenase | alcoholism | ischemia | chaperone | neuroprotective | dopamine neurons | rotenone | MPTP | substantia nigra
Small molecule activator of ALDH2
Chemical nameN-(benzo[d][1,3]dioxol-5-ylmethyl)-2,6-dichlorobenzamide Parent CAS No.[349438-38-6] |
| 產(chǎn)品資料 |
