| 產(chǎn)品名稱(chēng) | DEAB - NSC 8782 |
| 產(chǎn)品貨號(hào) | Axon 2476 CAS [120-21-8] MF C11H15NOMW 177.24 Purity: 99% Soluble in DMSO Description Potent inhibitor of cytosolic (class 1) aldehyde dehydrogenase (ALDH) enzymes (IC50 values 0.057 μM, 1.2 μM, 3.0 μM, 1.2 μM, 0.16 μM, and 13 μM for inhibition of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, and ALDH5A1, respectively). DEAB was also found to be an excellent substrate for ALDH3A1, and an irreversible inhibitor of ALDH7A1 (KI value 100 μM). Low turn-over rates and/or covalent bonding of the ALDH substrate DEAB are the cause of its inhibitory effect on the enzymes. At the time of development DEAB was found to be a potent inhibitor of cytosolic ALDH1 but not mitochondrial ALDH2. Commonly used as “selective” inhibitor of ALDH isoenzymes in cancer stem cell biology. References Certificates Categories Extra info C.A. Morgan et al. N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes. Chem Biol Interact. 2015 Jun 5;234:18-28. ? M.I.Mahmoud et al. Effect of 4-(diethylamino)benzaldehyde on ethanol metabolism in mice. Alcohol Clin Exp Res. 1993 Dec;17(6):1223-7. ? M. Luo et al. Diethylaminobenzaldehyde is a covalent, irreversible inactivator of ALDH7A1. ACS Chem Biol. 2015 Mar 20;10(3):693-7. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Diabetes & Metabolism Stem Cell ALDH EC 1.2.1.36 Potent inhibitor of cytosolic (class 1) aldehyde dehydrogenase (ALDH) enzymes Chemical name 4-(diethylamino)benzaldehyde Parent CAS No. [120-21-8] Order Size Unit Price Stock 10 mg €50.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢(xún)價(jià)，電話(huà)：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
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| 產(chǎn)品詳情 |
DEAB - NSC 8782Axon 2476 CAS [120-21-8] MF C11H15NO
Description
Potent inhibitor of cytosolic (class 1) aldehyde dehydrogenase (ALDH) enzymes (IC50 values 0.057 μM, 1.2 μM, 3.0 μM, 1.2 μM, 0.16 μM, and 13 μM for inhibition of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, and ALDH5A1, respectively). DEAB was also found to be an excellent substrate for ALDH3A1, and an irreversible inhibitor of ALDH7A1 (KI value 100 μM). Low turn-over rates and/or covalent bonding of the ALDH substrate DEAB are the cause of its inhibitory effect on the enzymes. At the time of development DEAB was found to be a potent inhibitor of cytosolic ALDH1 but not mitochondrial ALDH2. Commonly used as “selective” inhibitor of ALDH isoenzymes in cancer stem cell biology.
Potent inhibitor of cytosolic (class 1) aldehyde dehydrogenase (ALDH) enzymes
Chemical name4-(diethylamino)benzaldehyde Parent CAS No.[120-21-8] |
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