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產(chǎn)品名稱

Sitamaquine - WR 6026 tosylate

產(chǎn)品貨號(hào)

Axon 1515 CAS [1019640-33-5] MF C21H33N3O.C7H8O3SMW 515.71 Purity: 99% Soluble in DMSO Description Dose-dependent and orally available inhibitior of complex II (succinate dehydrogenase or SDH) of the respiratory chain in digitonin-permeabilized promastigotes. A potential agent as an oral treatment of life-threatening visceral leishmaniasis (VL) caused by Leishmania donovani (EC50 value 19.8 μM for L. donovani promastigotes in vitro). References Certificates Categories Extra info A.M. Due?as-Romero et al. Interaction of sitamaquine with membrane lipids of Leishmania donovani promastigotes. Biochim. Biophys. Acta. 2007, 1768, 246-252. ? C. López-Martín et al. Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes. Antimicrob. Agents Chemother. 2008, 52, 4030-4036. ? L. Carvalho et al. The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase. Antimicrob. Agents Chemother. 2011, 55, 4204-4210. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Diabetes & Metabolism Immunology Succinate dehydrogenase EC 1.3.5.1 Succinate dehydrogenase inhibitor with anti-Leishmanial activity Chemical name N,N-Diethyl-N'-(6-methoxy-4-methyl-quinolin-8-yl)-hexane-1,6-diamine tosylate Parent CAS No. [57695-04-2] Order Size Unit Price Stock 10 mg €120.00 In Stock

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現(xiàn)貨詢價(jià)，電話：010-67529703

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產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Sitamaquine - WR 6026 tosylate

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 1515

CAS [1019640-33-5]

MF C21H33N3O.C7H8O3S
MW 515.71

Purity: 99%
Soluble in DMSO

Sitamaquine

Description

Dose-dependent and orally available inhibitior of complex II (succinate dehydrogenase or SDH) of the respiratory chain in digitonin-permeabilized promastigotes. A potential agent as an oral treatment of life-threatening visceral leishmaniasis (VL) caused by Leishmania donovani (EC50 value 19.8 μM for L. donovani promastigotes in vitro).

A.M. Due?as-Romero et al. Interaction of sitamaquine with membrane lipids of Leishmania donovani promastigotes. Biochim. Biophys. Acta. 2007, 1768, 246-252.

C. López-Martín et al. Sitamaquine sensitivity in Leishmania species is not mediated by drug accumulation in acidocalcisomes. Antimicrob. Agents Chemother. 2008, 52, 4030-4036.

L. Carvalho et al. The 8-aminoquinoline analogue sitamaquine causes oxidative stress in Leishmania donovani promastigotes by targeting succinate dehydrogenase. Antimicrob. Agents Chemother. 2011, 55, 4204-4210.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Diabetes & Metabolism Immunology Succinate dehydrogenase EC 1.3.5.1

Succinate dehydrogenase inhibitor with anti-Leishmanial activity

Chemical name

N,N-Diethyl-N'-(6-methoxy-4-methyl-quinolin-8-yl)-hexane-1,6-diamine tosylate

Parent CAS No.

[57695-04-2]

產(chǎn)品資料

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