| 產(chǎn)品名稱 | Niraparib - MK 4827 |
| 產(chǎn)品貨號(hào) | Axon 2928 CAS [1038915-60-4] MF C19H20N4OMW 320.39 Purity: 100% Optical purity: Optically pure Soluble in DMSO Description Niraparib is a potent, selective and orally available PARP 1/2 inhibitor with IC50 values of 3.8 and 2.1 nM, respectively. Moreover, in a whole cell assay, Niraparib inhibited PARP activity with an EC50 value of 4 nM and inhibited proliferation of cancer cells with mutant BRCA-1 and BRCA-2 (CC50 value of 10?100 nM). Niraparib was well tolerated in vivo and demonstrated efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer. KEYWORDS: Niraparib | supplier | PARP inhibitor | MK 4827 | MK4827 | MK-4827 | CAS [1038915-60-4] | CAS [1038915-64-8] | CAS [1038915-73-9] | DNA-RNA | PARP | Inhibitor | Enzymes | BRCA |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
Niraparib - MK 4827Axon 2928 CAS [1038915-60-4] MF C19H20N4O
DescriptionNiraparib is a potent, selective and orally available PARP 1/2 inhibitor with IC50 values of 3.8 and 2.1 nM, respectively. Moreover, in a whole cell assay, Niraparib inhibited PARP activity with an EC50 value of 4 nM and inhibited proliferation of cancer cells with mutant BRCA-1 and BRCA-2 (CC50 value of 10?100 nM). Niraparib was well tolerated in vivo and demonstrated efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer. KEYWORDS: Niraparib | supplier | PARP inhibitor | MK 4827 | MK4827 | MK-4827 | CAS [1038915-60-4] | CAS [1038915-64-8] | CAS [1038915-73-9] | DNA-RNA | PARP | Inhibitor | Enzymes | BRCA
Potent, selective, and orally available PARP1/2 inhibitor
Chemical name(S)-2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide Parent CAS No.[1038915-60-4] |
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